Clinical Reasoning, as a means to an end, for the development of Self Actualisation as a primary care Musculoskeletal Physiotherapist
by Martin Krause (1999-2008)
The science of navigation can be taught, the art of navigation needs to be learnt through experience.
Art is about the experience of questioning conventional paradigms.
The conundrum for health professions is that 'statistically' we work within a 95% confidence interval. Hence, when working with human bodies we are invariably working on the edge of the unknown. By using a structured reasoning approach we can eliminate variables from a list of probabilities, eventually defining the essence of the clinical picture. Hereby the umbrella diagnosis which incorporates everything but means nothing (eg Non-specific low back pain) is eliminated.
These pages present a structure and a process to the art of learning clinical reasoning. It will encourage the reader to interpret all findings, be curious of why some things work and others don't, and why some things work most of the time but not all of the time. It will also endeavor to provide a navigational chart of learning whereby the clinician can excel whilst standing on the shoulders of clinical research giants.
Experts don't store answers, rather they store key facts and strategies which help them gain those answers. Hereby, they use long term memory that has taken at least 10 years of concentrated effort using metacognitive and reflective thinking strategies. Experts tend to recruit larger areas of the brain for information processing thereby increasing their RAM capacity. Neurons that fire together, wire together. This leaves the short term memory free for processing novel stimuli.
Expert opinion lies on the lowest rung of the Evidence Based Practice (EBP) hierarchy. However, the process of Practice Based Evidence (PBE) should form an integral part of every treatment strategy and hereby provide a catalyst for EBP. One form of consensus decision making is the Delphi approach whereby several experts are asked an opinion about a presentation. During a second round, the experts are shown all other opinions and then asked to rank those opinions. The objective is to use several rounds of questions and answers to narrow down the opinions to those which are most likely or more probably. The following is a summary of the processes needed clinically to develop ones clinical opinion expertise and how interaction with the client and other professions can lead to an optimised management strategy and hence treatment outcome. Hereby, Dogma is reduced and many avenues of thought are accommodated.
"fish live in the sea, therefore all things in the sea are fish"
One of the crucial ingredients of successful education is the ability to learn from mistakes. Structured clinical reasoning should limit those mistakes to within a margin of safety. Unstructured reasoning, in a wealth of information creates a poverty of attention.
"it ain't what you don't know that gets you into trouble. It's what you should know for sure that just ain't so"
"Liberate your mind and only then will you find your freedom"
Table of Contents
Mind Maps - clinical examples
Clinical reasoning is the process by which the Musculoskeletal Physiotherapist assesses the client's dysfunction. Titled Australasian Musculoskeletal Physiotherapists are trained in the superior clinical reasoning skills required for independent self-directed reasoning. The cognitive and meta-cognitive skills required for clinical reasoning may lead to expertise if applied clinically for at least 10 years. This process not only allows the clinician to recognize their limitations, moreover it empowers the clinician to know how to plug any gaps in their knowledge by either researching a particular topic and/or attending post-graduate training courses (self directed learning). These skills are founded under the umbrella of life long learning (the 3 L's).
It is important for the clinician to
- Identify and prioritise professional and personal goals they want to achieve in a set time frame.
- Recognise the key components of effective goal setting.
- Clearly define goals based on their organisational role.
- Motivate themselves and their team to attain their goals.
- Identify key obstacles to achieving individual and team goals.
- Create action steps to accomplish individual and team goals.
- Develop techniques to ensure follow through.
Hereby, the clinician can try to optimise the environment in which they wish to thrive.
However, Taylor (1979, 1986, 1987) described 4 phases of development which include
and associated transition points that result in
- disconfirmation - major discrepancy between expectations and experience
- disorientation - confusion and a crisis of confidence
- naming the problem - without blaming self or others
- exploration - open ended exploration with a gathering of insights, confidence and satisfaction
- reorientation - a major insight with a simultaneous new approach to learning/teaching/treatment
- sharing the discovery
- equilibrium - new approach is elaborated, refined and applied
Clinical Reasoning is analogous to travelers on a highway. Some are the drivers, others are the passengers. Through experiential learning, the passengers curiosity and confidence can be aroused to become a driver. All the travelers must obey the same road rules, yet they all have a different skill set. The road rules are the consensus of professional practice, whereas the skill set reflects experiential clinical learning. The highway represents the algorithmic structure of assessment, inductive and deductive reasoning. This highway becomes a freeway once these algorithms are rehearsed and automated from frequently repeated subjective and physical examinations. Similar to highways linking towns, the examination links historic events and involvement of body structures, which have either precipitated or have become involved with the current dysfunction. Once the travelers arrive in the town, they experience a more complicated maze of streets with innumerable possibilities. Similarly, as the clinician hones-in on the precise nature of the problem, the experienced clinician uses a more nebulas reasoning process, which may resemble 'fuzzy logic' whereby they recognize clinical patterns based on their unique past experiences or they recognize a novel clinical reasoning experience, which will require inductive as well as deductive reasoning. Similarly, the travelers in the town can use more cumbersome roads to get to their destination or they may know a more optimal route based on examination of the street directory, previous learning, as well as asking local people for advice. In particular, the experienced clinician has the wisdom to acknowledge their own limitations and thereby know when to ask specialists for advice and refer their clients to them. However, there are many clinicians who can become trapped by their own biases, which certainly can help their specific group of clients. Yet, have they had the skills to recognize where treatment hadn't been optimal? Have they contributed to the client ending up on an orbital freeway, unable to get off and explore the town and hence alternative possibilities for reaching their destination through novel management of their condition?
An exciting approach to challenging realities is the examination of the Pain and Philosophy of the Mind (Alex Cahana July 2007, Pain Clinical Updates, Vol XV, 5). Cahana argues that 'mind-body supervenience' (physicalism or materilism) where pain always has a physical substrate, isn't enough to explain the qualitative nature/character of pain ("qualia" = what it is to be).
The problem with physicalism as argued by Cahana is that 'you are nothing but your synapses' ("eliminative") or 'you are ultimately your synapses' ("reductive" or "token").
Cahana (2007) concludes by stating that "pain cannot be separated from the person experiencing it, and the human experience cannot be omitted from a scientific explanation of how our mind works. Therefore, a new subjectivist, interpretive, phenomenological stance is needed in order to capture the complexity of the patient's narrative experience (narrative dyad)".
Thoughts lead to feelings which lead to either action or inaction whereby either activation or deactivation of problem solving takes place. This applies as much to the therapist as to the client who is suffering from pain. Through clinical prediction, environmental prediction can be more finely tuned by the feelings which have preceded the situation that has taken place. The therapist and the client need to embark in cognitive strategies which include ascertaining feelings and beliefs, appraising the adequacy of the response and then if necessary using problem solving to be able to use realistic goal setting (rather than fear -avoidance behaviour) to establish a paced response. Success (by the therapist and the client) leads to better predictive outcomes and thereby should become self-fulfilling.
Figure 1: A model of predictive reasoning which has been propagated in physiotherapy since the early 1990's (based on the work of Barrows & Tamblyn 1980)
C.B.T = cognitive behavioural therapy ; N.L.P = neuro-linguistic programming
Figure 2 Multiple hypothesis formation and refinement of management strategies
Ultimately, the clinical reasoning process can be divided into a process of confirmation or negation either through positive diagnostic testing (eg Faber's test, Speed's test etc etc) with their inherent problems of validity and reliability or the process can involve treating a structure and evaluating the outcome by re-examining both the impairment and disability issues which the client presented with. The clients cognitive-linguistic appraisal of outcome can also be evaluated through the re-evaluation of the significant findings from the subjective examination.
Mind maps are a useful guide for the experienced clinician as they not only chunk together information but also provide a sequential structure for processing multiple information. Mind maps can provide a useful schemata for 'brain storming' and lateral thinking. Furthermore, mind maps provide a useful clinical aid to explaining cause and effect to the client, particulalry when multiple sites of pain are present. Links to mind maps of some clinical conditions
- tennis elbow
- anterior hip pain
- hamstring injuries
- pelvic neck dysfunction in a cyclist
- Upper Cervical Spine Structural Instability
- Nutritional considerations and cramping in triathlon
- Knee pelvis back dysfunction in a runner with overactive Transverse Abdominus
- arm pain from L5 IVD hernia (with reference to FBL and Susanne Klein Vogelbach)
- pins and needles, numbess in cyclists feet - including biomechanical & vascular compromise
- carpal tunnel syndrome from upper cervical spine dysfunction? - including biomechincal & vascular compromise
- Gastrocnemius tightness - including biomechanics (inverse dynamics, young's modulus, kinetic energy)
As the physiotherapist gains clinical expertise their predictive reasoning or forward thinking should improve. The majority of our cognitive processing occurs in our subconscious whereby routines only change when their is a variation to our expectations. As such, the repeatedly rehearsed, systematic and structured clinical reasoning routine allows for cognitive efficiency. The experienced clinician can 'chunk' clinical patterns into recognizable objects, whereby many variables can be grouped into a meaningful piece of information. Since, the conscious brain can only process one piece of information at any one time, and only hold 6 pieces of information in short term memory, the reduced cognitive demands of 'chunking' allows the experienced clinician to increase the scope of their clinical expertise. Particularly, in more complex multi-dimensional musculoskeletal problems the Musculoskeletal Physiotherapist should be able to apply a multi-dimensional treatment approach. The discerning Musculoskeletal Physiotherapist uses correlations between disability measures with impairment measures such as restrictions in motion, altered form & force closure, inefficient force transmission, as well as cognitive behavioural factors to ascertain whether they are dealing with a familiar or unfamiliar 'clinical pattern'. The validity of each treatment technique is ascertained by their impact on disability and impairment measures. Predictive reasoning and a successful outcome confirms already established 'clinical patterns' or allows for the recognition of a new 'clinical pattern'. This new 'clinical pattern' can then be laid down into the long term memory and be used by the more efficient subconscious reasoning at a later date. Thus, similar to a 'grand master' chess player recalling thousands of strategic moves from famous games, the experienced clinician can recall clinical patterns and the processes needed to confirm these patterns in an efficient manner.
More precise research and formulation of clinical reasoning concepts has come from Mark Jones and his collaborators, in South Australia. Categories of reasoning which an experienced clinicians undertake include
- Diagnostic reasoning
- Narrative reasoning
- Procedural reasoning
- Interactive reasoning
- Collaborative reasoning
- Reasoning about teaching
- Predictive reasoning
- Ethical reasoning
Hereby, they have presented arguments for undertaking research paradigms which provide evidence for the superiority of this approach over protocol recipe based approaches. Moreover, the clinical reasoning approach supports/validates the use of techniques which improve disability and impairment measures. Hence, the physiotherapist and client can achieve immediate gratification when improvements are demonstrated. Similarly, if improvements are not forthcoming, then the process allows analysis and re-analysis (cognition and meta-cognition) of strategies already undertaken and rational decisions can be made because of the systematic nature of this approach. Thus, both the client and physiotherapist can actively learn during this process.
La Havana, Cuba, 1995
When considering continuing education some issues of neuro-linguistic programming (NLP) may become relevant to physiotherapists.
Neuro = neurological processes affecting thoughts and emotions and subsequent behaviour
Linguistic = communicate with others and influence experience
Programming = internal thoughts and patterns of behaviour that help evaluate situations, solve problems and make decisions.
Achieving excellence requires
- effective communication
- motivation of yourself and others
- thinking positively
- creating actions to make a difference
OUTCOMES : should be S.M.A.R.T = specific, measurable, achievable, realistic, timeframe
- Creating a well formed outcome means that your goals are stated positively, is clearly context defined, and identifies the resources you need to achieve your goal. Remember each journey commences with a single step
- Flexibility is about acknowledging that everyone interprets situations through their own perceptions, thereby creating their own reality. Situations change with an ever-changing environment. Flexibility allows you to gather information from a variety of sources, from different perspectives and from different points of view.
- Rewiring your thinking involves changing your habits, developing new approaches to old situations, replacing limiting thoughts with enabling ones thereby gaining a new perspective.
- Language filters include deletion, distortion and generalization.
- Identify who you are, where your beliefs and values lie, what your capabilities are, and in what environment will your behaviour change when challenging your ability to reach your purpose in (professional) life.
- Map out a structure which reflects both your personal and professional goals starting from some point in the past and going to some specific time in the future to enable you to be yourself. By identifying your time-line, you will be able to pace yourself as you acquire the tools to reach your goals.
- To create mastery through self-directed learning you need to go through 4 stages of learning a new skill
Unconscious incompetence : learning a new skill for the first time, not knowing what you don't know
Conscious incompetence : realizing what you don't know and what you still need to learn
Conscious competence : building the new skill and capability, and feeling familiar with them
Unconscious competence : expertly using the tools like they were second nature (e.g. driving a car)
Hence, the post graduate learning which you undertake should reflect the analysis of yourself.
A word of warning
Consider the Schroedinger's Cat phenomenon where the observer's observations affect the outcome. Clinically, a uni-dimensional approach may always seem to achieve the desired outcome, thereby never really testing yourself, nor encouraging you to improve your clinical competency base. If there is little which you are looking for then there is little which you will see, and that which you see will be what you want to see. Incredibly, some of the people who frequently write the text books aren't clinicians. The most extreme case I know is a physiotherapist with only 4 years clinical experience who is writing a book 'about everything to do with musculoskeletal physiotherapy'. So, try to gain your practical clinical experience from as many sources as you possibly can, as people with a guru status often come with a bias. The best people to teach clinical expertise are clinicians. Particularly, if you are going to undertake post-graduate physiotherapy training make sure that the facilitators are current and have at least 10 years post graduate clinical experience. Peter O'Sullivan at Curtin University and Gwen Jull from Queensland University are two brilliant clinicians which spring immediately to mind. Other people who I've had the good fortune to meet and who have embark on a process of clinical excellence are Alfio Albasini of Ticino (Switzerland), Wim Dankaerts from Belgium, Abrahao Batista from Salvador do Bahia (Brasil) and Luis Henriquez from Santiago de Chile.
The clinician/researcher who is able to construct the question, have firstly realize a problem which requires the framing of a solution through the formulation of possibilities, probabilities, improbabilities and unknowns. Hereby, they are on the road to finding an answer, which along the way may throw up some new and intriguing questions as well as solutions.
Importantly, the ultimate cognitive goal for deductive and inductive clinical reasoning is to attain and store knowledge in a coherent and meaningful structure, ready for quick retrieval. In the face of clinical pattern recognition, the working hypothesis can be tested and re-tested and altered as clinical findings come to light.
If there are only
- 5 primary colours (red, green, blue, black & white),
- 5 basic notes (A, G, B, D, F)
- 5 basic tastes (sweet, sour, bitter, savoury, salty)
- 5 types of intelligence found in literature (scientific, philosophy, serious fiction, history, poetry)
which can give rise to an infinite number of combinations, then what are the quintessential elements of physiotherapy?
Figure 3: A model of 'everything' ?: the neuromatrix is used as a model (cognitive process oriented structure) to describe the various input which the therapist can offer to 'enable' the client to engage in their path to recovery. Hereby, an evidence based approach using 'the values and beliefs' of the client is integrated with the scientific evidence base from physiotherapy, the pain sciences and psychology. Importantly, the therapist gains confidence through their success at predictive reasoning, whilst the client gains emotional confidence in their ability to undertake goal-oriented activities without the fear of exacerbation or under-performance. A definition of expertise should encompass the ability to perform accurate predictive reasoning.
"Gardner defines intelligence as the capacity to solve problems or to fashion products that are valued in one or more cultural settings. MI initially consisted of seven dimensions of intelligence (Visual / Spatial Intelligence, Musical Intelligence, Verbal/Linguistic Intelligence, Logical/Mathematical Intelligence, Interpersonal Intelligence, Intrapersonal Intelligence, and Bodily / Kinesthetic Intelligence). Since the publication of Frames of Mind, Gardner has additionally identified an 8th dimension of intelligence: Naturalist Intelligence, and is still considering a possible ninth: Existentialist Intelligence "- see Wikipedia
Human's are prone to taking short-cuts known as "heuristics". Although they generally serve us well, they often cause clinicians to make predictable errors. Generally, biases favor hawkish advice. These include
- the optimism bias. People are prone to exaggerating their strengths. People generally believe themselves to be smarter, more attractive and more talented than average. They commonly overestimate their future success. This can lead to "illusion of control" whereby they consistently exaggerate the amount of control they have over outcomes, even when those outcomes are determined by luck or other variables.
- the fundamental attribution error. Even when people are aware of the possible constraints on another persons behaviour and know a lot about the context in which the client is acting, they often don't take it into account when assessing the client's motives.
- risk aversion bias. An assumption is frequently made that people are "risk averse" but it turns out that we are predominantly "loss averse". The clinician may be prepared to run a risk in the slim hope of avoiding having to recognise a loss.
Due to the ease of being drawn into 'pattern recognition' and hence potential biasing, it is important for the clinician to maintain a structured cognitive retrieval process whereby recognition of desired and undesired outcomes leads to conformation or negation of the clinical reasoning hypothesis. Hopefully, when negation does occur, it occurs early in the reasoning process; otherwise the treatment management plan can spiral 'out of control' leading to the therapist taking greater and greater risks in the hope for a miracle. Hence, the clinician will need to be able to think back to first principles of anatomy, physiology, neurophysiology, pathology and biomechanics to be able to undertake the process of reasoning required to achieve the desired outcome. This formulation of outcome should in turn be a consequence of the dialogue within the therapist's brain (cognition & meta-cognition) as well as the dialogue between the client and the therapist.
Constructivism describes the process of learning and acquiring knowledge through experiential reasoning. The assumption underlying 'constructivism' is that we are 'life long learners' (3 l's) and that each and every clinical encounter allows a unique opportunity to learn, relearn and refine our techniques as well as reorganise and restructure our knowledge base. Furthermore, constructivist theory suggests that learning occurs which is based on each individuals unique prior experiences. Truth is considered relative to the individuals construct and hence diverges from logical positivism of science where 'truth' can exist alone without reference to the observers perceptions. This is similar to scientific philosophy of 'relative truths' or the 'relativity of knowledge' espoused by Feyerabend (1975), Kuhn (1970), Popper (1963). All of us would agree that science isn't just a collection of laws, or a catalogue of unrelated facts. Rather, it is a creation of the human mind relating to making sense of the world. Hence, in musculoskeletal physiotherapy we must endeavour to match the science with our clinical reasoning which should make sense to the individual or organisations with whom we are interacting.
Candy (1991, p 263) states that "the constructivist perspective differs significantly from the view of knowledge as deriving from a process of copying or replicating." Hence, "we know reality only by acting on it.....The active interaction between the individual and the environment is mediated by the cognitive structures of the individual......and what we learn from the environment is dependent upon our own structuring of those experiences." (Nystedt and Magnusson 1982, p34)
To the constructivist, knowledge is not a precise map of external reality but a schemata or cognitive structure which can be compared or tested to other peoples construction of the same situation through the use of workable hypothesis or templates (Candy 1991, p 265). Domain specific prior knowledge plays a significant role in the process of construction, problem solving and learning. Systematic procedures for problem solving can be learnt which if content and context specific can lead to advanced clinical reasoning where errors in heuristic procedures can be detected immediately through the continuous testing of the working hypothesis and it's evaluation of the relevance of clinical data to the specific problem at hand. Hereby, not only can reliance on 'heuristics' be monitored but new schemata can be construed from the clinical environment when a clinical presentation occurs with which the clinician is unfamiliar.
Heuristics versus Constructivism
Figure 4: A useful instructional model used to describe a 'top-down' clinical approach with a scientific clinical evidence based approach of biomechanics and neurophysiology. Importantly, the cognitive and meta-cognitive aspects of clinical reasoning are only as good as the diagnostic tools available to the therapist. Hence, excellent manual handling skills and refined but diverse treatment techniques (e.g. trigger point dry needling, soft tissue massage, fascial release, muscle energy, exercise prescription, taping, PAIVM's and PPIVM's) allow for a correlated and integrated approach to treatment. Refinement of reasoning techniques requires frequent repetition of experiential learning.
Clinical Reasoning can be a conduit for the deconstruction and reconstruction of information storage and retrieval systems. This systematic approach allows for the redefining of the situational relevance of perceived information into a 'meaningful clinical picture' whereby correlation of information can be used to confirm or negate a 'reasoning (working) hypothesis'. "Mindfulness" and "Mindsight" has been used by Dan Siegler (2010) to describe the correlation of subjective internal realities with external physical realities. Similarly, Geoff Maitland developed a process of clinical reasoning, in the 1970's, whereby the 'meaning' of information is ascertained through the intra-correlation of the subjective experience with the intra-correlated physical presence or being.
Figure 5: Increasing the validity and reliability of the clinical reasoning process by correlating all aspects of the subjective and physical examination into a meaningful clinical picture (pattern recognition) - adapted from Maitland (1986, 1991). Click on above image for further explanations regarding the development of the Maitland concept.
An example of the sequence of physical exmination for a problem in the back-pelvis-hip region. To provide validity of this management approach, the results of the physical examination and treatment must be correlated with the findings in the subjective examination. Hence, meaning and relevance of the physical examination and treatment can only be obtained through the clients 'subjective quantifiable' experience. In this manner an integrated coherent narrative can be attained by both the therapist and the client, thus allowing a harmonious client-therapist relationship to ensue.
It is important to appreciate that there isn't a linear relationship between impairment and disability. Disability contains quality of life perspectives which has psychological and social constructs as well as the more visible physically measurable impairments. Health Quality of Life (HQoL) gives the physiotherapist with another avenue to pursue evidence-based practice (EBP) which include the third pillar of EBP, patient values. (see O'Connor R 2000 Measuring Quality of Life in Health. Edinburgh: Churchill Livingston. ISBN: 0443073198)
When traumatic events involving anxiety and/or pain occur, they can be stored in memory using a process which does not distinguish a timeline of activation or extinguishment of the experience. Hereby, previous traumatic experiences can be conceived as a present traumatic experiences causing further fear and anxiety. Ramachandran has suggested that it can be the preoccupation with the trauma that is disabling. Hence, the concept of allostasis has been included in the neuromatrix described previously in figure 3. Psychometric evaluation is now considered mandatory in NSW when treating work accident related cases.
The Oerebro scale is another useful psychometric questionaire which is recommended by Work Cover NSW
Other areas of assessment may include
- visual fields and visual dominance
- spatio-temporal abilities such as juggling
- sport specific physical and psychological aspects
This latter aspect of assessment may include a 'top 10' attributes list compiled by the client/athlete of both physical and mental performance in an ideal world. Then the therapist can ask the athlete to rate their present sport specific perceived abilities. Additionally, their coach may also be presented the same list and ask them to rate the athletes abilities. This is obviously undertaken without the coach seeing what the athlete thought of themselves. Hence discrepancies can be assessed, measured and addressed. Psychological aspects can be addressed by a Sports Psychologist whereas the physical aspects can be addressed in tandem with the Psychologist, Physiotherapist and Trainer.
Although an at 'out of fashion' terminology, the aggravating/easing factors are a disability measure which can be used to assess the neurophysiological and biomechanical state of the pathology. By analyzing the movement and loading characteristics of the aggravating and easing factors the therapist should gain a measurable outcome tool for assessing the efficacy of treatment. Additionally, the information can be used to correlate it with impairment measures of the physical examination. Improving the internal reliability by correlating information across the entire examination process enhances the validity of your treatment and re-examination process. Ideally, the therapist should have at least 3 aggravating/easing factors to assess outcome. Otherwise, a more in depth analysis of the aggravating/easing factors should be undertaken using inductive reasoning. For example, if the client only complains of shoulder pain when lifting a load above their head, then clarify this statement by asking whether it is the movement which is painful, the duration of lifting, the manner of lifting or the size of the load which is being lifted that is significant. Night pain, the frequency of waking and the ability to return to sleep are also useful measurement tools. Psychometric disability measures can also be used if they don't result in resentment or irritation from your client.
Further aspects of the subjective examination can be used to assess the past history as it relates to the current problem. Is it the same problem re-aggravated or is it a new problem which is influenced by the old injury? Assess the biomechanical aspects of the original mechanisms of injury as well as those of re-exacerbation, as well as the frequency of exacerbation and make a judgement as to whether the problem is getting worse, better or staying the same. If it is getting worse, then why? Are there components of misuse (reduced co-ordination/stability), disuse (atrophy and reduced capacity of loading), abuse (trauma), or overuse (repetitive loading and microtrauma) which are contributing to the 'cause of the cause' of the problem. A long history of problems may identify fear-avoidance behaviour and generalised 'disuse' and/or of more specific 'disuse' of the multifidus and transverse abdominis muscles. Combine this with 'overuse' of the erector spinae muscles leading to excessive compression of the intervertebral disc and consequent neural irritation of the dorsal root ganglia resulting in ectopic impulse generation and increased muscle tone in the deep hip rotators, hip flexors, hamstring and calf muscles which creates 'misuse' of the lower limbs ('the tail that wags the dog phenomena') generating shearing and rotating forces across the pelvis.
There are TWO areas of the clients history that are able to give you an accurate prediction of injury
1. Past Injuries – regardless of how long ago the injury happened
2. Current exercise training volume – obviously the higher the training volume the higher the risk of developing overuse and biomechanical injuries.
A good history should include:
a) Past Injuries – especially those that resulted in surgery, joint disturbances and scar tissue
b) General Health – a rundown client does not recover as well and is more prone to overuse injuries
c) Colds and Flu – limited recovery is available when the client is recovering from general and common medical disorders
d) Sporting Background – some athletic populations have common injury areas e.g. tennis players elbows, swimmers shoulders, gymnasts have excessive flexibility and stability issues in their backs and shoulders, and wicketkeepers knees.
e) Exercise History – clients often mention that they exercised in the past but had to stop due to injury – this information is vital as combined with a physical assessment you can identify the causative factors and re-structure their exercise program to avoid the same mistakes again.
f) Current Exercise Problems – is there any current exercise or activity that causes pain during or after the session.
g) Employment History – certain lines of work also have increased risks of injury for certain body parts. Office workers can have muscle range limitations, truck drivers can have back issues due to excessive vibration and carpet layers commonly have knee and back issues.
Old injuries may not only reduce the biomechanical integrity of the tissue but it may also increase the neurophysiological sensitivity of the neurones whose nerve fibres innervate the territory of injury. Ascertaining the recuperation from previous injury will provide an insight into the clients 'active' and/or 'passive' coping strategies. People who have had frequent passive treatment inputs and have recovered may find it difficult to embrace a more active treatment approach. Those who haven't recovered may be in a state of 'learned helplessness' who will similarly require convincing to embark on a more active form of recuperation. Importantly, the active treatment approach must embrace the impairment and disability measures of the subjective and physical examinations, thereby allowing the client to measure success leading to the ultimate goal of full self management and/or complete recovery. Therefore, this process requires an element of education whereby the therapist's 'hands-on' treatment becomes 'exercise enabling' and/or 'performance enhancing' for the client.
Figure 6 : The application of treatment will vary with the stage, stability, severity and irritability of the condition. The stage describes whether the condition is getting better, worse or staying the same. The stability is considered both mechanically and neurophysiologically. The severity is the impact the injury has on the person's activities of daily living. The irritability defines how easily the symptoms worsen and relates to how quickly they get better. These factors will influence the goals of the client which should direct the aims and objectives of the therapist. In line with Maslow's formulation of individuals 'needs' the process of clinical reasoning and perfection of treatment skills should lead to expertise in the clinical domain and subsequently to a state of "self actualisation" As the physiotherapist's success and treatment scope improve, self actualisation can be attained through their reflective skills, which enables the therapist to recognise 'gaps' in their integrated knowledge base. Such realisation should result in actively seeking the knowledge and/or competency skills required to reduce the size and number of 'gaps'. However, this expertise can only be gained through the 3L's.
Maslow (1971, p43) defined the attributes of "self actualizers" to include
- the acceptance of self and others
- spontaneity and naturalness
- autonomy and independence
- freshness of perception
- genuineness in relationships with others
- positive self concept
- involvement in a cause outside of themselves
Figure 7 : Defining the aspects of the examination heightens the therapists cognitive abilities and hence clinical agility. Reflective skills as treatment is instigated and outcomes are measured enhances the therapist's meta-cognitive skills (thinking about their thinking)
Figure 8 : Examining the 'cause of the cause' will get to the root of the problem. By deconstructing the problem, clear and precise explanations can be given whereby the aims and objects of treatment commensurate with the goals of exercise
The stage, stability, irritability, and severity will determine treatment options as well as the dose of treatment - here an example for a lumbar radiculopathy is given
Treatment is usually directed at the primary problem for which the client has presented. As the primary problem resolves the cause and affect of the injury must be taken into consideration if an holistic approach is to be considered. Low back pain would address issues of thoracic spine stiffness in rotation, lateral bending and inferior lateral chest expansion as these areas influence the lateral movement of the diaphragm during breathing. In turn this affects the use of the oblique stomach muscles, the transverse abdominus and psoas major. Furthermore, the ganglia of the sympathetic nervous system attach to the anterior aspect of the posterior ribs and their function is influenced by rib movement, which can potentially affect the control of muscle spasms and blood flow to the spine and lower limbs. Finally, deep slow lateral breathing reduces the risk of respiratory alkalosis and hence metabolic acidosis which can affect soft tissue integrity. Looking below the lumbar spine, addressing the pelvis and hips using joint mobilizations, soft tissue massage and muscle energy techniques would affect lumbo-pelvic rhythm. Muscle spasms can be addressed by reducing inflammation and/or relieving mechanical pressure on nerve fibres thereby decreasing ectopic impulse generation. Additionally, dry needling and soft tissue massage of the muscle fibres may also be employed. Exercise regimes to complement the specific impairment outcome measures should be integrated into functional exercises which resemble activities of daily living. Naturally, the clients motivational & emotional state needs to be monitored if a collaborative approach to recovery is to be obtained.
In most cases musculoskeletal disorders resolve within 6 weeks. Where greater structural damage has occurred, the resolution of impairment and improvement in disability can take 6-12 months. However, in some cases, dysfunction becomes prolonged causing suffering and reduced vitality.
Reasons for failure of resolution are numerous. However, generally they can be classified as simple or complex. Simple problems are localized dysfunction which wasn't managed correctly in the acute phase resulting in disuse impairment and de-conditioning. Such de-conditioning can take on multiple dimensions. Where a simple ankle sprain leads to atrophy of the leg muscles, reduced cardiovascular fitness, increased weight, neurological-immune-cognitive impairment and even metabolic syndrome. Complex problems arise where multiple structures in various locations have been injured in scenarios of major trauma such as car accidents, skydiving, gun shot wounds, etc. Again, the secondary issues of trauma involving whole body function are the consequence of prolonged recovery. In both cases active involvement by the client in the rehabilitation process are paramount. Moreover, the role of the physiotherapist is to reduce impairment and introduce exercise appropriate for the time line of recovery.
Sporting expertise is gained through repetition of movement and avoidance of (and appropriate recovery from) injury. Frequently, being painfree was considerd to be synonymous with recovery. However, researchers at Queensland University clearly demonstrated that recurrences in injury can be the result of continued abnormal motor function.
In some cases neuro-cognitive issues, arising from 'fear-avoidance' behaviour, occur. This is frequently due to altered sensory information processing. In such cases the client is given the appropriate amount of information to load the body to make it stronger. It is paramount to understand that the intensity and duration of pain is usually not commiserate with 'tissue damage'. In fact 'the pain' now has become the pathology.
The immune system, muscle mass and exercise tolerance can have a profound influence on the clients adaptability to stress, exercise and inflammation. The therapist will need to consider the general health of the client, and in particular their lean muscle mass, when assessing and treating the clients problem. The clients lean muscle mass not only determines biomechanical power, the ability to use insulin, resorb lactic acid to pyruvate by the liver and function as the metabolic end product of the electron transfer chain (ETC) in the mitochondria for endurance outputs, it also directly influences the ability to mobilise immune proteins for an inflammatory defense reaction.
The immune system respond in specific ways to exercise prescription. - link to Rome Presentation
The specificity of goal oriented exercise prescription, can be used for positive immune adaptive responses. - link to nutritional supplementation
Goal oriented exercise prescription and health management regimes can be used to aid the client with their predictive reasoning and hence their adaptive allostatic physiological and behavioural responses. - link to neuro-immune response
Forward thinking (predictive reasoning) as it pertains to the gaining of expertise in orienteering, motor learning, avoidance of injury and pain management
Sometimes it is hard to know what you don't know. It's important not to be constrained by dogma. In each case recognize what you know and compare this with what you don't know. Hereby, a risk analysis can be undertaken to establish the wisdom of your treatment. "A wise person knows their limitations". As each day brings a new dawn, plugging the gaps in your knowledge through life long learning (the 3 L's) can be a most satisfying experience. If you study hard and gain clinical insights from as many respected fields of clinical science as you possible can, you will be able to enhance the scope of your practice and thereby prevent burn-out by recognizing and enjoying the greater challenges of holistic musculoskeletal care. This will not only be to the satisfaction of your clients but also to the greater good of your community. However, the path is a long one, where clinical expertise requires at least 10 years of dedicated learning. I've been a physiotherapist for over 20 years and yet every day brings with it a potentially new learning experience.
Terapia Manual y dolor (Castellano)
Dolor y Inflammacion (Castellano) PDF
Beispiel von Klinisches Denken (Deutsch)
Important vascular issues include those of the vertebral artery in the cervical spine. A commonly held belief is that these incidence (-catastrophic or otherwise) are rare with a prevelance of 1 : 100 000. However, the true number may be much greater, as many catastrophic incidents are under - reported due to medico-legal reasons. In my clinical experience, by 2008 I had seen approximately 12 clients with VBI and a further 8 who had petit mal seizures or vaso-vagal syncope with mobilisations to the first rib. The majority of the clients with the 'classic' symptoms of VBI had either a prior incidence from manipulation of the C/S or had a major accident involving the neck - car accidents prior to seat belts, and horse riding incidents were frequently reported. Even a train crash was reported. By 2008 I estimated that I had seen approximately 60 000 clients. Hence, my 20 : 60 000 ratio suggest a 1 in 3000 chance of coming across a client with VBI.
A form of pins & needles in the feet during cycling may be due to claudication. Such claudication may be the result of damage to vessels of the abdominal aortic. Additionally the branches of the abdominal aorta descending into the leg as well as the leg vasculature may be damaged by trauma and/or systemic complications (e.g. Marfan's syndrome, vascular diseases, etc). These problems may be a medical emergency whereby immediate consultation with a vascular surgeon is imperative.
Virchow's Triad in the aetiology of thrombosis may also be of assistence with differential diagnosis. The 3 variables include
- Changes in vessel wall (endothelial damage)
- Changes in blood flow (flow volume/stasis)
- Changes in blood constituents (state of coagulability)
The latter may include screening questions for blood disordes (thrombolytic ones, C-reactive protein , Leiden Factor V, as well as Thalasaemia and Sickle Cell Anaemia), systemic inflammatory conditions (such as Lupus and Scleroderma), the use of oral contraceptives, smoking, diet and frequent flying.
Taylor & Kerry (2005) quote a paper from Sise et al (1989) reporting an average 2 year delay in diagnosis in young people where 93% could have been diagnosed with simple palpation of peripheral pulses.
from Gray's Antaomy
Vascular complications are potentailly overlooked causes of symptoms. This in part may be due to their relative infrequency compared with other conditions seen by physiotherapists. Futhermore, the symptoms of vascular compromise may mimic those of symptoms arising from musculoskeletal structures. Compromise of a blood vessel to the spinal nerve results in radicular pain. A colleague reported the incidental finding of a family friend's teenage boy whose mother was about to take him to the chiropractor for low back pain. What he noted was the boy had 3 socks on his left foot!!! Immediate examination of the lack of pedal pulses and referal to the A+E department confirmed a diagnosis of spinal artery thrombosis. Unfortunately, most peoples friends aren't astute clinicians that recognise "something which doesn't make sense". Arterial kinking of the external iliac artery during hip flexion whilst cycling (and rowing, skatting and Fjell running) have been known to produce pain affecting the buttock, anterolateral thigh, calf and foot with feelings of paraesthesia and numbness in the toes. Cyclists may also describe the feeling of 'fullness' in the leg and lack of power, cramping and/or ischeamic like fatigue. Although anterior/posterior and lateral compartment syndromes are commonly associated with vascular complications in running, similar type (not necessarily area) of symptoms associated with iliac artery, femoral artery and popliteal artery can be missed during the clinical reasoning process. Generally, symptoms are associated with exertion and external compromise of the blood vessel. Apart from the iliac artery already mentioned other examples include the femoral artery in the adductor canal (b/n the adductor magnus and vastus medialis), and the politeal artery interfacing with the medial head of gastrocnemius. Generally, these conditions are associated with anatomical anomalies whereby the external pressure from repetitive movement gradually damages the external lining of the blood vessel. Besides repetitive microtrauma, any external trauma from an accident needs to consider possible vascular damage or the formation of scar tissue and adhesions which could lead to vascular damage. Other clinical examples, include aortic aneurysm which may be due to valsava type maneuvers. Familial history may also be important in differential diagnosis. Additionally, a history of heavy smoking can lead to internal blood vessel pathology. Similarly, women who take the pill may also be at risk. Aortic stenosis may manifest as a result of arterosclerosis or due to underlying congenital defects. These are screening questions which need to be asked during the subjective examination. During the physical examination, the femoral and pedal pulses should be examined at rest but usually need to be assessed immediately after exercise or in the compromising posture where symptoms normally manifest. Further testing should include ankle blood pressure monitoring of each side. Taylor & Kerry (2005) recommend 20 minutes of rest before testing systolic blood pressure in the left and right brachial artery, posterior tibial and dorsalis pedis and then using the "Ankle to brachial pressure index = Ankle systolic BP / Brachial systolic BP". 1 - 1.2 considered normal, 0.75 - 0.9 indicates moderate disease, 0.5 - 0.75 severe disease and <0.5 is limb threatening. (see: Taylor AJ, Kerry R (2005) Vascular syndromes presenting as pain of spinal origin. Ch 36 in Grieve's Modern Manual Therapy: The Vertebral Column. Ed Boyling JD & Jull GA Elsevier Churchill Livingstone).
The Upper Limb and vascular compromise
from Grays Anatomy
The posture of the cyclist (and rower) may also make these athletes particularly prone to upper limb and head/neck vascular conditions. Additionally, one of the most common cycling injuries involves landing on the shoulder or outstretched hand resulting in possible neurovascular traction injury, direct trauma and/or clavicular fracture. The latter has been associated with trapezius muscle dysfunction which can be a precipitating variable leading to Thoracic Outlet Syndrome (TOS). Symptoms of TOS can include typical symptoms of neck, shoulder, elbow and hand pain. Occasionally, people describe a sense of swelling (or fullness) in the arm, with/without concommitant pins & needles or numbness. Vascular components of TOS may be less prevelant than neurological ones. Yet this may be due to mis-diagnosis as the plethora of tests (Adson's, Allen's Halstead's manoeuver, Roos's EAST test) may be falsely positive or negative and variable b/n examiners. Hence, the examination must use the multitude of variables at the clinicians disposal, both Subjective symptoms & Physical signs - inductive and deductive reasoning, to make sense of the clincal picture. When in doubt and further investigations are required, by using the weight of probability from many variables, it may also make the argument for further testing more convincing to a medical colleague.
Paget - Schroetter syndrome is a deep venous thrombosis of the subclavian - axillary venous system, also known as "effort thrombosis" (Rutherford 1998, Zell et al 2001) and may account for about 3-7% of all DVT's (Taylor & Kerry 2005). The average patient is in their late 20's to early 30's and males present 3 times more commonly than females. Most commonly complain of quick insidious arm pain (70% in dominant arm), with possible supraclavicular fossa and ipsilateral neck pain. Most commonly occurs in activity with repetitve upper arm, over shoulder height, movements. The usual aetiology is Virchow's Triad which means that specific screening questioning is required. Additionally, other risk factors may include thoracic outlet factors such as cervical rib, anomalous first rib, hypertrophy of the anterior scalene, subclavius or pectoralis minor as well as endogenous factors such as activated protein C resistance and anticardiolipin antibodies (Ellis 2000 in Taylor & Kerry 2005).
Taylor & Kerry suggest that observable signs of vascular compromise may include skin pallor or cyanosis - both resting and positional, swelling, and/or superficial venous dilation. Corneal arcus or xanthelasmas (yellowish raises skin changes) around both eyes may be associated with hyperlipidaemia and hypercholesterolaemia. Staining of fingers may be a more accurate indicator of tobacco consumption. Obesity and state of mental awareness may also reflect underlying cerebrovascular state.
Hand and digital examination should also include nail squeezing - indicative of capillary refilling time. These should be perfomed in various positions of potential vascular compromise. Nail abnormalities may be present. Pulses should be tested, stethescope auscultation should be undertaken and the pressure cuff sphygmomanometer and hand held doppler or automatic blood pressure monitor used (Taylor & Kerry 2005).
Taylor & Kerry (2005) argue quite strongly that vascular examination is such a miniscule part of both under-graduate and post-graduate degrees that we may be implicated in delayed diagnosis and initiating innapropriate treatment.
Clinical example : Facial Numbness
Thalassemia (British English: thalassaemia) are forms of inherited autosomal recessive blood disorders that originated in the Mediterranean region. In thalassemia, the disease is caused by the weakening and destruction of red blood cells. Thalassemia is caused by variant or missing genes that affect how the body makes hemoglobin. Hemoglobin is the protein in red blood cells that carries oxygen. People with thalassemia make less hemoglobin and fewer circulating red blood cells than normal, which results in mild or severe anemia.
Thalassemia can cause significant complications, including pneumonia, iron overload, bone deformities and cardiovascular illness. However this same inherited disease of red blood cells may confer a degree of protection against malaria, which is or was prevalent in the regions where the trait is common. This selective survival advantage on carriers (known as heterozygous advantage) may be responsible for perpetuating the mutation in populations. In that respect, the various thalassemias resemble another genetic disorder affecting hemoglobin, sickle-cell disease.
Factor V Leiden, also known as Leiden Factor 5 (and sometimes factor VLeiden) is the name given to a variant of human factor V that causes a hypercoagulability disorder. In this disorder, the Leiden variant of factor V cannot be inactivated by activated protein C. Factor V Leiden is the most common hereditary hypercoagulability disorder amongst Eurasians
Drug Side Effects on the Musculoskeletal System
- muscle stiffness from drug side-effects
- acne treatment with Accutane :
A medical officer sent me the following details
"Roaccutane can cause myalgia and arthralgia, and they found this on DermNetNZ:
Muscle aches (myalgia) especially after exercise. Low backache is not uncommon. Joint aches (arthralgia) especially after exercise can sometimes be debilitating. These symptoms respond to nonsteroidal anti-inflammatory drugs such as ibuprofen.
In MIMs (Australian Drug Directory):
Musculoskeletal and connective tissue disorders. Myalgia, arthralgia and increased serum creatine phosphokinase may occur and may be associated with reduced tolerance to vigorous exercise (see Adverse Reactions).
In clinical trials of disorders of keratinisation with a mean dose of 2.24 mg/kg/day, a high prevalence of
skeletal hyperostosis was noted. Bone changes including premature epiphyseal closure and
calcifications of tendons and ligaments have occurred after administration of high doses for long periods
for treating disorders of keratinisation. The dose levels, duration of treatment and total cumulative
dose in these patients generally far exceeded those recommended for the treatment of acne.
Minimal skeletal hyperostosis has also been observed by X-rays in prospective studies of nodular acne
patients treated with a single course of therapy at recommended doses.
Due to the possible occurrence of these bone changes, a careful evaluation of the risk/benefit ratio should be carried out in every patient and Roaccutane administration should be restricted to severe cases."
- acne treatment http://accutane.poweradvocates.com/bone.html
- anti psychotic drugs for bi-polar disorder : http://bipolar.about.com/cs/sfx/a/sfx_thorazine.htm
- cholesterol treatment with statins : http://www.medicinenet.com/script/main/art.asp?articlekey=16431
- loss of bone density from drug side-effects
- anti depressant drugs and loss of bone density
This list is not exhaustive. Importantly it highlights the therapists need to be aware of the clients medication use and their possible side-effects.
Macrophages are necessary for skeletal muscle regeneration. Pro-inflammatory macrophages stimulate myoblast proliferation, whereas anti-inflammatory macrophages stimulate their differentiation. Macrophages that invade skeletal muscle soon after injury present a specific phenotype, characterized by high expression of TNF-alpha, interleukin-1beta and secretory leukocyte protease inhibitor (SLPI). Non-phlogistic phagocytosis of the apoptotic and necrotic debris switches the phenotype of pro-inflammatory macrophages into anti-inflammatory macrophages. Consequently, there is a high expression of Transforming Growth Factor- Beta (TGF-beta), interleukin - 10 (IL-10), and peroxisome proliferator-activated receptor - gamma (PPAR-gamma) which have been shown to be associated with the resolution of inflammation and tissue repair (Chazaud et al 2009). This may explain the inclonclusive effects of NSAID's for the treatment of DOMS. In fact it highlights the potential inhibitory effects of NSAID's on muscle proliferation when exercise training.
Examples of courses presented
- Neurophysiological Effects of Traction, Rigaku Ryohogaku (2000), 27,4, 128 (Japan)
- Lumbar Spine Traction: Evaluation of effects and recommended application for treatment (2000), Manual Therapy, 5, 2, 72-81
- Neurophysiological effects of Manual Therapy (1996), Kinesiologia, (Chile)
- Neurophysiological considerations of SLR and ULTT (1998), Kinesiologia (Chile)
- Whole Body Vibration Therapy and Training
Chaos theory and the Butterfly effect from conflicting descending modulating and peripheral input into the neurones of the spinal cord with inappropriate assessment and treatment
We comply with the HONcode standard for health trust worthy information:
Adams, M.A., Dolan, P.& Hutton, W.C. (1986). The stages of disc degeneration as revealed by discogram. Journal of Bone and Joint Surgery 68B , 36.
Ahmed, M., Bjurholm, A., Kreicbergs, A.& Schultzberg, M. (1993). Sensory and autonomic innervation of the facet joint in the rat lumbar spine. Spine 18 (14), 2121 to 2126.
Alkon, D.L.& Rasmussen, H.A. (1988). A spatial-temporal model of cell activation. Science 239 , 998 to 1005.
Attal, N., Filliatreau, G., Perrot, S., Jazat, F., Di Giamberardino, L.& Guilbaud, G. (1994). Behavioural pain-related disorders and contribution of the saphenous nerve in crush and chronic constriction injury of the rat sciatic nerve. Pain 59 , 301 to 312.
Badalemente, M.A., Dee, R., Ghillani, R., Chien, P-F. & Daniels, K. (1987). Mechanical stimulation of dorsal root ganglia induces increased production of substance P : A mechanism for pain following nerve root compromise? Spine 12 , 552 to 555.
Barasi, S.& Lynn, B. (1986). Effects of sympathetic stimulation on mechanoreceptive and nociceptive afferent units from the rabbit pinna. Brain Research 378 , 21 to 27.
Barker, J.N., Mitra, R.S., Griffiths, C.E., Dixit, V.M.& Nicholoff, B.J. (1991). Keratinocytes as initiators of inflammation. Lancet 337 , 211 to 214.
Barrows, H.S., Tamblyn, R.N., (1980). Problem-based learning: an approach o medical education. Springer, New York.
Blottner, D.& Baumgarten, H.G. (1994). Neurotrophy and regeneration in vivo. Acta Anatomica 150 , 235 to 245.
Bogduk, N. (1993). The anatomy and physiology of nociception. In : Crosbie J.& McConnell, J.(Eds.) (1993). Key Issues in Musculoskeletal Physiotherapy (Ch.3). Oxford : Butterworth-Heinemann Ltd.
Butler, D.S., (1991). Mobilisation of the Nervous System . Churchill Livingstone : Melbourne.
Candy, PC (1991) Self Direction for Life Long Learning : Jossey Bass Publishers : San Francisco
Chazaud B, Brigitte M, Yacoub-Youssef H, Arnold L, Gherardi R, Sonnet C, Lafuste P, Chretien F (2009). Dual and Beneficial Roles of Macrophages During Skeletal Muscle Regeneration. Exercise and Sports Science Reviews, 37, 1, 18 to 22
Chatani, K., Kawakami, M., Weinstein, J.N., Meller, S.T.& Gebhart, G.F. (1995). Characterization of thermal hyperalgesia, c-fos expression, and alterations in neuropeptides after mechanical irritation of the dorsal root ganglion. Spine 20 (3), 277 to 290.
Coderre, T.J., Basbaum, A.I.& Levine, J.D. (1989). Neural control of vascular permeability : interactions between primary afferents, as cells, and sympathetic efferents. Journal of Neurophysiology 62 , 48 to 58
Coderre, T.J., Chan, A.K., Helms, C.& Levine, J.D. (1991). Increasing sympathetic nerve terminal-dependent plasma extravasation correlates with decreased arthritic joint injury in rats. Neuroscience 40 , 185-189.
Coghill, R.C., Mayer, D.J., Price, D.D., (1993). Spinal cord coding of pain : The role of spatial recruitment and discharge frequency in nociception. Pain , 53 , 295-309.
Cohen, M.L., (1995). The clinical challenge of secondary hyperalgesia. Moving in on Pain (Abstracts). Adelaide, Australia.
Cohen, M.L., Quintner, J.L., (1993). Fibromyalgia syndrome, a problem of tautology. Lancet , 342 , 906 to 909.
Collingride, G.L.& Singer, W. (1990). Excitatory amino acid receptors and synaptic plasticity. Trends in Pharmacological Science 11 , 290 to 296.
Cornefjord, M., Takahashi, K., Matsui, H., Olmarker, K., Holm, S.& Rydevik, B. (1992). Impairment of nutritional transport at double level cauda equina compression: An experimental study. Neuro Orthopedics 13 , 107 to 112.
Dickenson, A.H.& Sullivan, A.F. (1987). Evidence for a role of the NMDA receptor in the frequency dependent potentiation of deep rat dorsal horn nociceptive neurons following C-fibre stimulation. Neuropharmacology 26 , 1235 to 1238.
Donnerer, J., Amann, R. & Lembeck, F. (1991). Neurogenic and non-neurogenic inflammation in the rat paw following chemical sympathectomy. Neuroscience 45 (3), 761 to 765.
Enwemeka, C.S. & Spielholz, N.I. (1992). Modulation of tendon growth and regeneration by electrical fields and currents. In : Currier, D.P.& Nelson, R.M. (Eds.) (1992). Dynamics of Human Biologic Tissues (ch10). Philadelphia : F.A. Davis Company.
Ferrell, W.R., Wood, L. & Baxendale, R.H. (1988). The effect on acute joint inflammation on flexion reflex excitability in the decerebrate, low-spinal cat. Quarterly Journal Of Experimental Physiology 73 , 95 to 102.
Galea, M.P. & Darien-Smith, I. (1995). Voluntary movement and pain : Focussing on action rather than perception. Moving in on Pain . Adelaide.
Gallin, J.I., Goldstein, I.M. & Snyderman, R. (Eds.) (1992). Inflammation : Basic Principles and Clinical Correlates (2nd ed.). New York : Raven Press.
Gogas, K.R., Presley, R.W., Levine, J.D. & Basbaum, A.,I., (1991). The antinociceptive action of supraspinal opioids results from an increase in descending inhibitory control : Correlation of nociceptive behaviour and C-fos expression. Neuroscience 42 (3), 617 to 628.
Gracely, R.H., Lynch, S.L. & Bennett, G.,J. (1992). Painful neuropathy : Altered central processing, maintained dynamically by peripheral input. Pain 51 , 175 to 194.
Greenbag, P.E., Brown, M.D., Pallares, V.S., Tompkins, J.S. & Mann, N.,H., (1988). Epidural anesthesia for lumbar spine surgery. Journal of Spinal Disorders 1 , 139 to 143.
Gonzales, R., Goldyne, M.E., Taiwo, Y.O. & Levine, J.D. (1989). Production of hyperalgesic prostaglandins by sympathetic postganglionic neurons. Journal of Neurochemistry 53 , 1595 to 1598.
Gonzales, R., Sherbourne, C.D., Goldyne, M.E. & Levine, J.D., (1991). Noradrenaline-induced prostaglandin production by sympathetic postganglionic neurons is mediated by alpha-2-adrenergic receptors. Journal of Neurochemistry 57 , 1145 to 1150.
Green, P.G., Basbaum, A.I., Helms, C. & Levine, J.D. (1991). Purinergic regulation of bradykinin-induced plasma extravasation and adjuvant-induced arthritis in the rat. Proceedings of the National Academy of Science , U.S.A. 88 , 4162 to 4165.
Green, P.G., Luo, J., Heller, P.H. & Levine, J.D. (1992). Modulation of bradykinin-induced plasma extravasation in the rat knee joint by sympathetic co-transmitters. Neuroscience 52 , 451 to 458.
Groen, G.J., Balget, B. & Drukker, J. (1988). The innervation of the spinal dura mater: anatomy and clinical considerations. Acta Neurochirurgica 92 , 39 to 46.
Groenblad, M., Weinstein, J.N. & Santavirta, S. (1991). Immunohistochemical observation on spinal tissue innervation. Acta Orthopaedic Scandinavia 62 (6), 614 to 622.
Groenblad, M., Virri, J., Tolonen, J., Seitsalo, S., Kaeaepae, E., Kankare, J., Myllynen, P. & Karaharju, E. (1994). A controlled immunohistochemical study of inflammatory cells in disc herniation tissue. Spine 19 (24), 2744 to 2751.
Handwerker, H.O., Forster, C. & Kirchhoff, C., (1991). Discharge patterns of human C-fibres induced by itching and burning stimuli. Journal of Neurophysiology 66 , 307 to 317.
Harvey, G.K., Toyka, K.V. & Hartung, H.-P. (1994). Effects of mast cell degranulation on blood-nerve barrier permeability and nerve conduction in vivo. Journal of the Neurological Sciences 125 , 102 to 109.
Heller, P.H., Green, P.G., Tanner, K.D., Miao, F.J.-P. & Levine, J.D. (1994). Peripheral neural contributions to inflammation. Progress in Pain Management (1st ed.)(pp31-42). Seattle : IASP Press.
Hodges, P., Richardson, C., (1996). Inefficient muscular stabilisation of the lumbar spine associated with low back pain : A motor control evaluation of transverse abdominis. Spine , 21 , 2640-2650.
Hodges, P., Richardson, C., Jull, G., (1996). Evaluation of the relationship between laboratory and clinical tests of transverse abdominis function. Physiotherapy Research International , 1 , 30 to 40.
Hu, S. & Zhu, J. (1989). Sympathetic facilitation of sustained discharges of polymodal nociceptors. Pain 38 , 85-90.
Hsieh, J-C., Stahle-Backdahl, M., Hagermark, O., Stone-Elander, S., Rosenquist, G., Ingvar, M., (1995). Traumatic nociceptive pain activates the hypothalamus and the periaqueductal gray: a positron emission tomography study. Pain , 64 , 303 to 314.
Issekutz, T.B. (1992). Inhibition of lymphocyte endothelial adhesion and in vivo lymphocyte migration to cutaneous inflammation by TA-3, a new monoclonal antibody to rat LFA-1. Journal of Immunology 149 , 3392 to 3402.
Jaenig, W. (1985). Organization of the lumbar sympathetic outflow to skeletal muscle and skin of the cat hindlimb and tail. Review of Physiology, Biochemistry, Pharmacology 102 , 119 to 213.
Jaenig, W. & Koltzenberg, M. (1991). Receptive properties of pial afferents. Pain 45 , 77 to 85.
Jones, M., (1995). Clinical Reasoning and Pain. Manual Therapy , 1 , 17 to 24.
Jull, G., Zito, G., Trott, P., Potter, H., Shirley, D., Richardson, C., (1997). Inter-examiner reliability to detect painful upper cervical joint dysfunction. Australian Journal of Physiotherapy , 43 , 2, 125 to 129.
Kalso, E.A., Sullivan, A.F., McQuay, H.J., Dickenson, A.H., Roques, B.P., (1993). Cross-tolerance between Mu Opioid and alpha-2 Adrenergic receptors, but not between Mu and Delta receptors in the spinal cord of the rat. The Journal of Pharmacology and Experimental Therapeutics , 265 (2), 551 to 558.
Kambin, P., Abda, S. & Kurpici, F. (1980). Intradiskal pressure and volume recording : Evaluation of normal and abnormal intervertebral disks. Clinical Orthopedics 146 , 140.
Kawakami, M., Weinstein, J.N., Chatani, K.-I., Spratt, K.F., Meller, S.T. & Gebhart, G.F. (1994a). Experimental lumbar radiculopathy : Behavioural and histologic changes in a model of radicular pain after spinal nerve root irritation with chromic gut ligatures in the rat. Spine 19 (16), 1795 to 1802.
Kawakami, M., Weinstein, J.N., Spratt, K.F., Chatani, K-I., Traub, R.J., Meller, S.T. & Gebhart, G.F. (1994b). Experimental lumbar radiculopathy : Immunohistochemical and quantitative demonstrations of pain induced by lumbar nerve root irritation of the rat. Spine 19 (16), 1780 to 1794.
Kobayashi, S., Yoshizawa, H., Hachiya, Y., Ukai, T. & Morita, T. (1993). Vasogenic edema induced by compression injury to the spinal nerve root: Distribution of intravenously injected protein tracers and Gadolinium-Enhanced Magnetic Resonance Imaging. Spine 18 (11), 1410 to 1424.
Koltzenburg, M., Kees, S., Budweiser, S., Ochs, G. & Toyka, K.V. (1994). The properties of unmyelinated nociceptive afferents change in a painful chronic constriction neuropathy. In : Gebhart, G.F., Hammond, D.L. & Jensen, T. S. (Eds.) (1994). Proceedings of the 7th World Congress on Pain : Progress in Pain and Management (2nd ed.) (Ch.35). Seattle : IASP Press.
Korkala, O., Gronblad, M., Liesi, P. & Karaharju, E. (1985). Immunohistochemical demonstration of nociceptors in the ligamentous structures of the lumbar spine. Spine 10 , 156 to 157.
Kuslich, S.D., Ulstrom, C.L. & Michael, C.J. (1991). The tissue origin of low back pain and sciatica: A report of pain response to tissue stimulation during operation on the lumbar spine using local anaesthesia. Orthopedic Clinics North America 22 , 181 to 187.
Laird, J.M.A. & Bennett, G.J. (1993). An electrophysiological study of dorsal horn neurons in the spinal cord of rats with an experimental peripheral neuropathy. Journal of Neurophysiology 69 , 2072-2085.
Laird, J.M.A. & Cervero, F. (1990). Tonic descending infuences on receptive-field properties of nociceptive dorsal horn neurons in sacral spinal cord of rat. Journal of Neurophysiology 63 (5), 1022 to 1032.
LaMotte, R.H., Shane, C.N., Simone, D.A. & Tsai, E.F.P. (1991). Neurogenic hyperalgesia : Psychophysical studies of underlying mechanisms. Journal of Neurophysiology , 66 , 190-211.
Levine, J.D., Dardick, S.J., Roizen, M.F., Helms, C. & Basbaum, A.I. (1986). The contribution of sensory afferents and sympathetic efferents to joint injury in experimental arthritis. Journal of Neuroscience 6 , 3923 to 3929.
Levine, J.D., Goldstine, J., Mayes, M., Moskowitz, M.A. & Basbaum, A.I. (1986). The neurotoxic effect of gold sodium thiomalate on the peripheral nerves of the rat. Arthritis and Rheumatism 29 , 897-901.
Levine, J.D., Taiwo, Y.O., Collins, S.D. & Tam, J.K. (1986a). Noradrenaline hyperalgesia is mediated through interaction with sympathetic postganglionic neurone terminals rather than activation of primary afferent nociceptors. Nature 323 , 158 to 160.
Lotz, M., Vaughn, J.H. & Carson, D. (1988). Effect of neuropeptides on production of inflammatory cytokines by human monocytes. Science 241 , 1218 to 1221.
Lovick, T.A., (1991). Interactions between descending pathways from the dorsal and ventrolateral periaquaductal gray matter in the rat. In ; Depaulis, A., Bandler, R.,(eds). The Midbrain Periaqueductal Gray Matter . Plenium Press, New York, 101 to 120.
Lima, D., Esteves, F. & Coimbra, A., (1994). C- fos activation by noxious input of spinal neurons projecting to the nucleus of the tractus solitarius in the rat. In : Gebhart, G.F., Hammond, D.L. & Jensen, T.S. (Eds.) (1994). Proceedings of the 7th World Congress on Pain : Progress in Pain and Management (2nd ed.) (Ch.30). Seattle : IASP Press.
Liu, J., Roughley, P.J. & Mort, J.S. (1991). Identification of human intervertebral disc stromelysin and its involvement in matrix degeneration. Journal of Orthopedic Research 9 , 568 to 575.
Lundborg, G., (1988). Nerve Injury and Repair . Edinburgh : Churchill Livingstone
MacMillan, J., Schaffer, J.L. & Kambin, P. (1991). Routes and incidence of communication of lumbar discs with surrounding neural structures. Spine 16 , 2, 167 to 171.
Magal, E.L. (1990). Gangliosides prevent ischemia-induced down-regulation of protein kinase C in fetal rat brain. Journal of Neurochemistry 55 , 2126 to 2131.
Maitland, G.D. (Ed.) (1986). Vertebral Manipulation (5th ed.). London : Butterworths.
Maitland, G.,D., (Ed) (1991). Peripheral Manipulation . London : Butterworths.
Mao, J., Price, D.D., Coghill, R.C., Mayer, D.J. & Hayes, R.L. (1992). Spatial patterns of spinal cord [14C]-2-deoxyglucose metabolic activity in a rat model of painful peripheral mononeuropathy. Pain 50 , 89 to 100.
Markowitz, S., Saito, K., Buzzi, M.G. & Moskowitz, M.A. (1989). The development of neurogenic plasma extravasation in the rat dura mater does not depend upon the degranulation of mast cells. Brain Research 477 , 157 to 165.
Maslow AH (1971) The farther reaches of human nature. Viking : New York
Matsui, H., Olmarker, K., Cornefjord, M., Takahashi, K. & Rydevik, B. (1992). Local electrophysiological stimulation in experimental double level cauda equina compression. Spine , 17 (9), 1075 to 1078.
Maixner, W., Gracely, R.H., Zuniga, J.R., Humphrey, C.B & Bloodworth, G.R. (1990). Cardiovascular and sensory responses to forearm ischemia and dynamic hand exercise. American Journal of Physiology 259 , R1156 to R1163.
McKenzie, R.C. & Sauder, D.N. (1990). The role of keratinocyte cytokines in inflammation and immunity. Journal of Investigative Dermatology 95 , S105 to 107.
Morton, C.R., Siegel, J., Xiao, H.-M., Zimmermann, M., (1997). Modulation of cutaneous nociceptor activity by electrical stimulation in the brain stem does not inhibit the nociceptive excitation of dorsal horn neurons. Pain , 71 , 65 to 70.
Morgan, M.M., Sohn, J.-H., Lohof, A.M. Ben-Eliyahu, S. & Liebeskind, J.C. (1989). Characterization of stimulation-produced analgesia from the nucleus tractus solitarius in the rat. Brain Research 486 , 175 to 180.
Nakagawa, I., Omote, K., Kitahata, L.M., Collins, J.G. & Murata, K. (1990). Serotonergic mediation of spinal analgesia and its interaction with noradrenergic systems. Anesthesiology 73 , 474 to 478.
Nishizuka, Y. (1989). The family of protein kinase C for signal transduction. JAMA 262 , 1826 to 1833.
Ochoa, J.L. & Yarnitsky, D. (1993). Mechanical hyperalgesia in neuropathic pain patients : Dynamic and static subtypes. Annals of Neurology 33 , 465 to 472.
Olmarker, K., Rydevik, B., Holm, S. & Bagge, U. (1989). Effects of experimental, graded compression on blood flow in spinal nerve roots. A vital microscope study on the porcine cauda equina. Journal of Orthopedic Research 7 , 817 to 823.
Olmarker, K., Rydevik, B. & Nordborg, C. (1993). Autologous Nucleus Pulposus induces neurophysiological and histological changes in porcine cauda equina nerve roots. Spine 18 (11), 1425 to 1432.
Petersen, N.,P., Vicenzino, B., Wright, A., (1993). The effects of a cervical mobilisation technique on sympathetic outflow to the upper limb in normal subjects. Physiotherapy Theory and Practice , 9 , 149 to 156.
O?Sullivan, P., Twomey, L., Allison, G., Sinclair, J., Miller, K., Knox, J., (1997). Altered patterns of abdominal muscle activation in patients with chronic low back pain. Australian Journal of Physiotherapy , 43 , 91 to 98.
Post, C., Minor, B.G., Davies, M. & Archer, T. (1986). Analgesia induced by 5-hydroxytryptamine-depletion in rats. Brain Research 363 , 18 to 27.
Price, D.D., Long, S. & Huitt, C. (1992). Sensory testing of pathophysiological mechanisms of pain in patients with reflex sympathetic dystrophy. Pain 49 , 163-173.
Price, D.D., Mao, J. & Mayer, D.J. (1994). Central neural mechanisms of normal and abnormal pain states. In Fields, H.L. & Liebeskind, J.C. (Eds.)(1994). Progress in Pain Research and Management (1st ed.)(pp61-84). Seattle : IASP Press.
Proudfit, H.K. (1992). The behavioural pharmacology of the noradrenergic descending system. In : Besson, J.M. & Guilbaud, G. (Eds.)(1992). Towards the use of Noradrenergic Agonists for the Treatment of Pain (1st ed.). Amsterdam : Elsevier Science Publishers B.V.
Quintner, J.L., Cohen, M.L., (1994). Referred pain of peripheral nerve origin : an alternative to the 'myofascial pain construct'. Clinical Journal of Pain , 10 , 243 to 251.
Raja, S.N., Meyer, R.A. & Campbell, J.N. (1988). Peripheral mechanisms of somatic pain. Anesthesiology 68 , 571 to 590.
Rees, H., Sluka, K.A., Westlund, K.N. & Willis, W.D. (1994). Do dorsal root reflexes augment peripheral inflammation ? NeuroReport 5 , 821 to 824.
Ren, K., Randich, A. & Gebhart, G.F. (1990). Modulation of spinal nociceptive transmission from nuclei tractus solitarii : A relay for effects of vagal afferent stimulation. Journal of Neurophysiology 63 (5), 971 to 986.
Roberts, W.J. & Elardo, S.M. (1985). Sympathetic activation of unmyelinated mechanoceptors in cat skin. Brain Research 339 , 123-125.
Rothwell, N.J. & Hopkins, S.J. (1995). Cytokines and the nervous system II : actions and mechanisms of action. Trends in Neuroscience 18 , 130 to 136.
Rydevik, B.L., Brown, M.D. & Lundborg, G. (1984). Pathoanatomy and pathophysiology of nerve root compression. Spine 9 , 7 to 15.
Rydevik, B.L., Myers, R.R. & Powell, H.C. (1989). Pressure increase in the dorsal root ganglion following mechanical compression: Closed compartment syndrome in nerve roots. Spine 14 (6), 574-576.
Sandkuehler, J., Eblien-Zajjur, A., Fu, Q.-G. & Forster, C. (1995). Differential effects of spinilization on discharge patterns and discharge rates of simultaneously recorded nociceptive and non-nociceptive spinal dorsal horn neurons. Pain 60 , 55 to 65.
Sanjue, H. & Jun, Z. (1989). Sympathetic facilitation of sustained discharges of polymodal nociceptors. Pain 38 , 85 to 90.
Schmidt, R.F. (1990). Experimental arthritis. Pain (supp) 5 , S215.
Schmidt, R.F., Schaible, H.-G., Messlinger, K., Heppelmann, B., Hanesch, U. & Pawlak, M. (1994). Silent and active nociceptors : Structure, functions, and clinical implications. In : Gebhart, G.F., Hammond, D.L. & Jensen, T. S. (Eds.) (1994). Proceedings of the 7th World Congress on Pain : Progress in Pain and Management (Ch.16) (2nd ed.). Seattle : IASP Press.
Shindo, K., Tsunoda, S-T.& Shiozawa, Z. (1994). Muscle spasm induced sympathetic reflex bursts on microneurography in a case with pontine demyelination. Clinical Autonomic Research 4 , 299 to 302.
Schomburg, E.,D. & Steffens, H. (1992). On the spinal motor function of nociceptive afferents and enkephalins. In : Jami, L., Pierrot-Deseilligny, E. & Zytnicki, D. (Eds.)(1992). Muscle Afferents and Spinal Control of Movement (pp.395 to 400)(1st ed.). Oxford : Pergamon Press.
Suval, W.D., Duran, W.N., Boric, M.P., Hobson, R.W., Berendsen, P.B. & Ritter, A.B. (1987). Microvascular transport and endothelial cell alterations preceding skeletal muscle damage in ischemia and reperfusion injury. The American Journal of Surgery 154 , 211 to 218.
Taiwo, Y.O. & Levine, J.D. (1989). Prostaglandin effects after elimination of indirect hyperalgesic mechanisms in the skin of the rat. Brain Research 492 , 397 to 399.
Takahashi, K., Olmarker, K., Holm, S., Porter, R.W. & Rydevik, B. (1993). Double level cauda equina compression. An experimental study with continuous monitoring of intraneural blood flow in the porcine cauda equina. Journal of Orthopedic Research 11 (1), 104 to 109.
Thompson, S.W.N. & Woolf, C.J. (1991). Primary afferent-evoked prolonged potentials in the spinal cord and their central summation : Role of the NMDA receptor. In : Bond, M.R., Charlton, J.E. & Woolf, C.J. (Eds). Proceedings of the VIth World Congress on Pain (pp291 to 298). Amsterdam : Elsevier
Tillman, L.J. & Cummings, G.S. (1992). Biologic mechanisms of connective tissue mutability. In : Currier, D.P. & Nelson, R.M. (Eds.) (1992). Dynamics of Human Biologic Tissues (pp1-44). Philadelphia : F.A. Davis Company.
Torebjoerk, E. (1994). Nociceptor dynamics in humans. In : Gebhart, G.F., Hammond, D.L. & Jensen, T. S. (Eds.) (1994). Proceedings of the 7th World Congress on Pain : Progress in Pain and Management (Ch.19) (2nd ed.). Seattle : IASP Press.
Troisier, O. & Cypel, D. (1986). Discography: An element of decision. Clinical Orthopedics 206 , 70.
Urban, L. & Randic, M. (1984). Slow excitatory transmission in rat dorsal horn : Possible mediation by peptides. Brain Research 290 , 336 to 341.
Vaccarino, F., Guidotti, A. & Costa, E. (1987). Ganglioside inhibition of glutamate-mediated protein kinase C translocation in primary cultures of cerebellar neurons. Proceedings of the National Academy of Science , U.S.A. 34 , 8707.
Wall, P.D. (1995). Treatment of pain. Moving in on Pain . Adelaide.
Wall, P.D. & Devor, M. (1983). Sensory afferent impulse originate from dorsal root ganglia as well as from the periphery in normal and nerve injured rats. Pain 17 , 321 to 339.
Wall, P.D. & Melzak, R. (1989) (Eds.). Textbook of Pain , (2nd. ed.). Edinburgh : Churchill Livingstone.
Weinstein, J.N., Claverie, W. & Gibson, S. (1988). The pain of discography. Spine 13 (12), 1344 to 1348.
Williams, T.J. & Hellewell, P.G. (1992). Endothelial cell biology. Adhesions molecules involved in the microvascular inflammatory response. American Review of Respiratory Disease 146 , S45 to 50.
Wiltse, L.L., Fonseca, A.S., Amster, J., Dimartino, P. & Ravessoud, F.A. (1993). Relationship of the dura, Hofmann's ligaments, Batson's plexus, and a fibrovascular membrane lying on the posterior surface of the vertebral bodies and attaching to the deep layer of the posterior longitudinal ligament: An anatomical, radiological, and clinical study. Spine 18 (8), 1030 to 1043.
Woolf, C.J. (1983). Evidence for a central component of post-injury pain hypersensitivity. Nature 306 , 686 to 688.
Woolf, C.J. (1984). Long-term alterations in the excitability of the flexion reflex produced by peripheral tissue injury in the chronic decerebrate rat. Pain 18 , 325 to 343.
Woolf, C.J. & McMahon, S.B. (1985). Injury-induced plasticity of the fexor reflex in chronic decerebrate rats. Neuroscience 16 , 395 to 404.
Woolf, C.J., Shortland, P. & Sivilotti, L.G. (1994). Sensitization of high mechanothreshold superficial dorsal horn and flexor motor neurones following chemosensitive primary afferent activation. Pain 58 , 141 to 155.
Woolf, C.J. & Swett, J.E. (1984). The cutaneous contribution to the hamstring flexor reflex in the rat : an electrophysiological and anatomical study. Brain Research 303 , 299 to 312.
Woolf, C.J. & Wall, P.D. (1986). Relative effectivenss of C primary afferent fibres in evoking a prolonged facilitation of the flexor reflex in the rat. The Journal of Neuroscience 6 , 1433 to 1442.
Wright, A., Vicenzino, B., (1995). Cervical mobilisation techniques, sympathetic nervous system effects and their relationship to analgesia. In : Schacklock, M.,O., (ed.). (1995). Moving in on Pain , Butterworth-Heineman, 164 to 173.
Xavier, A.V., Farrell, C.E., McDanal, J. & Kissin, I. (1990). Does antidromic activation of nociceptors play a role in sciatic radicular pain? Pain 40 , 77 to 79.
Zochodne, D.W. (1993). Epineural peptides : A role in neuropathic pain? Canadian Journal of Neurological Sciences 20 (1), 69 to 72.
Last update : 22 February 2017