A Neurophysiological and Clinical Reasoning Approach to the selection of Dosage in Manual Therapy
Martin Krause
Bachelor of Applied Science (Physiotherapy), University of Sydney
Masters of Manipulative Physiotherapy, University of Sydney
Graduate Certificate Health Science Education, University of Sydney
Graduate Diploma Health Science (Exercise and Sport), University of Sydney
Certificate IV Workplace Assessment and Training
Private Practitioner, North Sydney, Australia.
Synopsis
In 1984 I was introduced to the world of joint mobilisations as advocated by the Geoff Maitland technique. These mobilisations were uniquely Australian, developed in South Australia, and gradually taught and disseminated around the world. The alternate form of manual therapy was developed in the Nordic countries by Freddy Kaltenborn. The techniques and philosophies differed markedly. The Maitland approach used oscillatory movements in the direction of pain provocation and were graded I -> IV. They respected pain, muscle spasms and resistance. Techniques involved small gliding accessory joint movements as well as passive physiological movements which were easily recognised, by a lay person, as resembling gross movements. In contrast, the Nordic method used sustained stretches and joint translations away from pain provocative movements. These movements were often a complex biomechanical construct of combined opening and closing or blocking movements. Later variations included the use of osteopathic derived techniques learnt by a group of international physiotherapists, at a workshop in the Canary Islands, around 1967.
The oscillatory techniques employed by the Australian approach were crudely based on the notion of 'pain gates' which existed in the spinal cord and basic biomechanical and anatomical concepts derived from Kapanji. Much later, descending cortical modulation and trans cortical control was used to explain efficacy. Basically, hypersensitised tissue was desensitised with gentle non-threatening stimuli. Later exercises were employed to gain and maintain the enhanced range of movement achieved, whilst concepts of stbilising exercises came at an even later date. Today, Australian physiotehrapy employs a complex array of multimodal techniques to treat multi-dimensional pain problems.
In essence, primary and secondary hyperalgesia need to be considered in terms of pain inhibited movement control. Reduction of the secondary driver of pain may allow greater loading of the primary driver, however the primary driver always needs to be cleared for full resolution to be achieved. Secondary and primary muscle atrophy needs to be considered in terms of reflexogenic loops from the joint receptor through the spinal cord and back out to the target organ (muscle). Secondary muscle atrophy can be functional from misuse, too much rest (disuse), abuse or overuse. Moreover, rather than examining the muscle as a purely biomechanical entity it has been demosntrated to be an extremely important organ of the immune system.
More recently, oscillatory movement control, in terms of a mass spring analogy of motor control which was employed in the 1980's, has been extropolated to include non-linear mechanics and chaos theory, which can be read elasewhere on this website.
Table of Contents
Neurogenic and non-neurogenic inflammation
Sympathetic modulation of inflammation and it's role in repair
The consequences of reduced receptor threshold to manual therapy
Secondary mechanical hyperalgesia due to oedema around the dorsal root ganglion
Spinal cord expansion of sensitised receptive fields
Manual therapy during peripheral and central expansion of the hypersensitive receptive field
Reduced movement due to expanded hypersensitive receptive fields
Effect of manual therapy on muscle acivity around the Intervertebral Foramen
The importance of dose in manual therapy
Descending inhibition in the modulation of pain
Motor control in the modulation of pain
Group III/IV muscle afferent feedback on endurance exercise performance
Game Theory and Muscle Synergy in the presence of pain
Cortical Resources and Muscle Representation
Introduction
Pain is a dynamic entity, which affects a large number of people around the world. Pain knows no cultural boundaries and people suffering from pain have been treated in various manners by various practitioners with various degrees of success for centuries. Modern medical and paramedical practice has attempted to come to terms with patient's ailments by diagnosing various pathologies with labels such as 'fibromyalgia', 'fibrocytis', 'repetitive strain injury', 'cervico-brachialgia', 'reflex sympathetic dystrophy', etc. However these labels may detract from effective clinical reasoning because
- the diagnostic criteria become so broad that it becomes difficult to exclude people from that diagnosis (Cohen & Quintner 1993; Quintner & Cohen 1994).
- the fundamental clinical reasoning principle for the production of symptoms is violated. i.e. a leap is made from signs and symptoms (phenomenology) to the assumption of disease (nosology) without consideration of pathophysiology (Cohen 1995).
To improve clinical reasoning skills it may be important for the clinical practitioner to understand the pathophysiology that underlies the phenomenology (Jones 1995). It is the objective of this paper to elucidate the mechanisms of pain and inflammation in a theoretical and clinical context. Improved understanding of pathology may provide the practitioner the context specific feedback to discover the most effective approach to treatment. Hence, the main argument which will be pursued here is that clinical signs and symptoms correlate with the underlying process of inflammation and repair. Thus, the dossage and type of manual therapy employed in the treatment of pain should reflect the normalisation of clinical signs and symptoms.
Inflammation
The reaction of living tissue to injury is called inflammation. Inflammation involves a cascade of events in cells, involving products of cells, enzymes, soluble factors, and blood vessels and their contents (Enwemeka & Spielholz 1992; Schmidt et al 1994; Tillman & Cummings 1992). Trauma to the intervertebral disc (IVD) may result in a focus of inflammation inside the disc (Weinstein et al 1988). Inflammatory substances may diffuse out of the IVD and contact the posterior longitudinal ligament, Batson's venous plexus, Hoffman ligaments and the dura mater (Adams et al 1986; Kambin et al 1980; Liu et al 1991; MacMillan et al 1991; Troisier & Cypel 1986). In contrast to the IVD, these later structures have a good blood supply and are densely innervated by sensory and sympathetic nerve fibres. Consequently, the nerve receptors and blood vessels may become inflamed directly from trauma and/or indirectly from inflammatory substances of IVD trauma (Korkula et al 1985; McLain 1993; Weinstein et al 1988; Wiltse et al 1993). Hence, inflammation and the resolution of inflammation may be synonymous with healing.
Inflammation and oedema
Inflammation may cause the formation of oedema and spinal pain (Barker et al 1991; Gallin et at 1992; Groenblad et al 1991;1994b; Kawakami et al 1994a; 1994b; McKenzie & Saunder 1990; Rothwell & Hopkins 1995; Rydevik et al 1989; Williams & Hellewell 1992). As oedema increases, compression of intraneural blood vessels and nerve fibres may preferentially decrease the conduction velocity of myelinated afferents and efferents, whilst probably leaving the conduction velocity along unmyelinated nerve fibres largely unaffected (Cornefjord et al 1992; Kobayashi et al 1993; Matsui et al 1992; Olmarker et al 1989; Rydevik et al 1984; Takahashi et al 1993). Decreased conduction along large diameter myelinated (type II) nerve fibres has been postulated to decrease the modulation (by wide dynamic range neurones [WDR]) of nociception in the spinal cord and thus increase pain (figure 1) (Dickenson & Sullivan 1987; Ochoa & Yarnitsky 1993; Price et al 1994).
Figure 1: Spinal cord modulation of pain. Wide dynamic range (WDR) neurone inhibition of nociceptive specific neurone (NS) in the dorsal horn of the spinal cord (adapted from Wall & Melzack 1989, pp11-13; Bogduk 1993, p59)
By implication, non-noxious mechanical stimuli from joint mobilisations may be ineffective where a decreased conduction along large diameter myelinated (type II) nerve fibres exists. Hence a more effective means of treatment may be one which normalises blood flow to neural tissue (eg. traction or a sustained rotatory technique) .
Neurogenic and non-neurogenic inflammation.
Inflammation involves a complex cascade of reactions at the peripheral receptor terminals. These reactions may be divided into two entities: neurogenic and non-neurogenic inflammation. Neurogenic inflammation includes the release of neuropeptides (e.g. substance P, Calcitonin Gene Related Peptide [CGRP], nordrenaline, etc) from C-fibre terminals whereas non-neurogenic inflammation involves the release of inflammatory substances (e.g. histamines, prostaglandins, cytokines, leukotrienes, bradykinin, etc) from the blood vessels and connective tissue. Both processes lead to a decrease in the activation threshold of the mechanoceptors.
Neurogenic inflammation is the process whereby neuropeptides released from C-fibres of primary afferents and sympathetic efferents cause vasculature membrane changes which results in the leakage of proteins from the vasculature into surrounding tissue (Ahmed et al 1991; Blottner & Baumgartner 1994; Donnerer et al 1991; Heller et al 1994; Kobayashi et al 1993; LaMotte et al 1991; Levine et al 1986; Markowitz et al 1989; Suval et al 1987; Zochodne 1993). In the absence of inflammation, sympathetic nerve fibre efferent terminals in experiments with rats (Hu & Zhu 1989) suppress C-fibre afferent receptor evoked discharges. However, during inflammation C-fibre receptors increase their neurogenic inflammatory response and hence increase their discharge frequency with stimulation of the sympathetic nerve terminals (Levine et al 1986). Sensitisation of peripheral nerve terminals by neurogenic and non-neurogenic inflammation may reduce mechanoceptors thresholds and contribute to pain (figure 2 and 3) (Groenblad et al 1991; Jaenig 1985; Lotz et al 1988; Handwerker et al 1991; Levine et al 1986a; Rees et al 1994; Raja et al 1988; Rothwell & Hopkins 1995; Schmidt et al 1994; Taiwo & Levine 1989).
Massive infiltration of macrophages into the dorsal root ganglion (DRG) was demonstrated in both the ipsilateral and contralateral lumbar but not thoracic DRG using the rat model of unilateral antigen-induced arthritis (AIA) in the knee (Segond von Banchet et al 2009). This activation wasn't explainable as a result of nerve cell lesion. During AIA lumbar but not thoracic DRGs exhibited bilateral de novo expression of vascular adhesion molecule (VCAM-1) which is known to be involved with macrophage infiltration. Chemical inhibtion of tumor necrosis factor alpha after induction of AIA significantly inhibited macrophage infiltration as well reduced the expression of VCAM-1. This also reduced mechanical hyperalgesia at the inflammed joint without attenuating the joint inflammation, additionally the mechanical hyperalgesia in the contralateral knee was also reduced. Thus, bilateral segment specific infiltration of macrophages into the DRGs is part of an unilateral inflammatory process in peripheral tissue and may be involved in the generation of peripheral mechanical hyperalgesia in the non-inflammed side (Segond von Banchet et al 2009).
Figure 2 : Schematic representation of the interaction between neurogenic and non-neurogenic inflammation on free nerve endings through the stimulation of mast cells. SNS = sympathetic nervous system. (adapted from Groenblad et al 1991, p617; Jaenig 1985; Lotz et al 1988; Handwerker et al 1991; Levine et al 1986a; Taiwo & Levine 1989).
Figure 3 : Percentageof mechanoceptors (group II, III, IV) responding to movement in the non-inflamed and inflamed states (Raja et al 1988; p576)
Sympathetic modulation of inflammation and its role in repair.
The sympathetic postganglionic nerves release inflammatory mediators that increase plasma extravasation, including prostaglandins (Coderre et al 1989; Gonzales et al 1991; Gonzales et al 1989; Green et al 1991). Additionally, under conditions of sympathetic postganglionic neuronal modulation bradykinin has been found to increase plasma extravasation (Green et al 1992). The sympathetic postganglionic neurones also release mediators which decrease plasma extravasation, including neuropeptide Y and noradrenaline (Green et al 1991;1992). Apart from modulating plasma extravasation these substances may also interact with endothelial relaxing factor (Greenberg et al 1991) and platelet-activating factor (Heller et al 1994) in the blood vessels. Agents that enhance synovial plasma extravasation have been demonstrated to decrease tissue injury during inflammation (Coderre et al 1991). The mechanisms by which sympathetic nerve terminals decrease tissue injury are unclear. However, an increased plasma extravasation would be expected to reduce the concentration of inflammatory substances through the facilitation of lymphatic and venous drainage, thereby improving repair (figure 4)(Heller et al 1994).
Figure 4 : Sympathetic modulation of peripheral nerve activity
The consequences of reduced receptor threshold to manual therapy.
At this stage it would appear that there are 2 mechanisms of modulation of electrical activity in type III and IV nerve fibres. These 2 mechanisms include
- non-noxious stimuli via the type II nerve fibres and WDR neurones and
- the peripheral sympathetic nervous system.
Significantly, WDR neurones probably respond specifically to the wide range of frequencies of input from the variations of force, frequency, direction and velocity which gentle oscillatory mobilisation techniques present. Consequently the type and dosage of techniques used need to reflect the normalisation of signs and symptoms. Further, the SNS is likely to respond to techniques which increase blood flow and lymphatic drainage whilst simultaneously being demonstrated to be non-threatening and effective to both the patient and the therapist. Thus, after each treatment technique the 'expected' normalisation of signs and symptoms need to be demonstrated. Similar to the paradox of Schroedingers Catin quantum physics, it is not until we observean effect do we know the effect. Yet our mere observation can affect clinical outcomes.
Secondary mechanical hyperalgesia due to the effect of oedema on the nerve roots/dorsal root ganglia/spinal nerve complex.
Endoneurial oedema of the dorsal root ganglia (DRG) may be the result of compression from inflammatory exudate (Chatani et al 1995). Endoneurial oedema of the DRG may generate ectopic electrical impulses (Bandalamente et al 1987). Ectopic impulses originating in the DRG are thought to propagate into the spinal cord and into peripheral receptor sites (Bandalamente et al 1987; Wall & Devor 1983). Increased neuronal firing may increase neurogenic inflammation at the receptor sites (Chatani et al 1995; Markowitz et al 1989; Xavier et al 1990). Arborization of peripheral nerve terminals may result in neurogenic inflammation in an expanded receptive field (LaMotte et al 1991). This suggests that extraneural inflammation may induce intraneural oedema that in turn may increase the intensity of extraneural neurogenic inflammation. In the case of the sinuvertebral nerve this may mean that receptors at multiple (eight) segments may become sensitised and exhibit decreased mechanical activation thresholds (Groen et al 1988; Koltzenburg et al 1994; Raja et al 1988). This area of neurogenic inflammatory expansion of the sensitised receptive field is termed secondary mechanical hyperalgesia (Raja et al 1988).
During surgery, retraction of the inflamed dura mater has been demonstrated to increase nerve impulse generation (Greenbarg et al 1988; Kuslich et al 1991). Therefore, the clinical implications of decreased activation threshold are a decreased dosage of treatment. Feedback of the effect of treatment on signs and symptoms may be a means of determining the effective dosage of treatment.
Interestingly, a projection of nerve fibres from the DRG to the pia mater of the ventral nerve root has been demonstrated in the cat (Jaenig & Koltzenburg 1991). Since electrical stimulation of the sympathetic nerve fibres has been demonstrated to sensitise mechanoceptors in rats (Barasi & Lynn 1986; Roberts & Elardo 1985; Snajue & Jun 1989), then ectopic impulse propagation due to mechanical irritation of the DRG may result in neurogenic inflammation of the ventral nerve root pia mater (Groenblad et al 1991; Harvey et al 1994; Wall & Devor 1983). However, the effect of neurogenic inflammation of the ventral nerve root on sympathetic b -fibre and a -motor fibre activity is theoretically and clinically uncertain.
Spinal cord expansion of sensitised receptive fields.
Spinal cord sensitisation (hypersensitivity) of adjacent wide dynamic range (WDR) and nociceptive specific (NS) neurones may occur due to the direct synaptic connections between adjacent WDR neurones and between adjacent NS neurones (figure 5)(Price et al 1994). Spinal cord expansion of the sensitised (hypersensitive) receptive field has been demonstrated and is thought to be a compensatory mechanism for the dissipation of the afferent barrage of electrical stimulation from sensitised (hypersensitive) peripheral receptors (Coghill et al 1991; LaMotte et al 1991; Magal 1990; Mao et al 1992; Price et al 1994; Torebjoerk et al 1992; Vaccarino et al 1987) and from ectopic impulse generation from the DRG (Wall & Devor 1983). Evidence for central expansion of the neuronal receptive field comes from the findings that if the nerve of the new hypersensitive receptive field of the adjacent dorsal horn neurones is ligated no expansion of the sensitivity of the peripheral receptive field occurs (Attal et al 1994). This suggests that in the presence of inflammatory exudate around the nerve root/DRG/spinal nerve complex and/or the sinuvertebral nerve then an adjacent peripheral nerve (e.g. sinuvertebral nerve, median nerve, etc,) may be recruited for the projection of neurogenic inflammation into adjacent areas of the spinal canal and/or limb.
Figure 5: Central expansion of the hypersensitive receptive field.
The significance of treating the pain with manual therapy during peripheral and central expansion of the hypersensitive receptive fields.
Both people in pain and therapists may have varying difficulty in localising the source of symptoms. Significant expansion of the hypersensitive receptive field may be postulated to result in increased acuity to detect the locus of dysfunction through a "3 dimensional map" of areas of normal activity and those of primary and secondary hyperalgesia. Perhaps the analgesic effect of gentle stroking around a painful area may be an example of this mechanism? Hence, in the case of referred neurogenic pain non-noxious manual therapy directed at the site of pathology may enhance the modulation of electrical activity in type III and IV fibres through mechanical input to aid in the detection of the locus of dysfunction.
Alternatively, expansion of the hypersensitive receptive field may be postulated to result in decreased ability to detect the locus of dysfunction. A clinical example of such a scenario may be when referred limb pain is more intense then the spinal pain at the site of pathology (eg spinal nerve/dorsal root ganglion/nerve root irritation). In this example it is highly probably that distal limb pain can be more severe than proximal pain due to the high density of mechanoceptors in the hands and the feet and their resultant disproportionate representation in the somatosensory cortex. (Interested readers should refer to somatosensory homunculus for further details). Therefore, in the case of projected neurogenic limb pain it may be hypothesised that unloading the site of secondary neurogenic inflammation (with for example tape) may increase the awareness of the primary site of pathology. Regardless of the effect of central expansion of the hypersensitive receptive field, it is highly likely that determination of the precise source of symptoms is necessary for effective healing to take place.
Clinically, the subjective examination includes a body chart which describes the area of pain. Hence, pain in a dermatological distribution which may be accompanied by pins & needles and numbness should result in the practitioner using a different line of clinical reasoning then that for referred somatic pain. Therefore, inductive questioning should reflect the responses from deductive questioning (figures 6 & 7).
Figure 6 : Reasoning involved differentiating Somatic from Radicular pain
Decreased movement due to the effect of expansion of spinal cord neuronal and peripheral receptor hypersensitivity associated with spinal and limb pain.
Several experiments have been designed to differentiate the contribution of peripheral receptors and spinal cord neuronal plasticity in pain production. Expansion of the hypersensitive receptive field (Price et al 1992) together with the decreased activation threshold of low and high threshold mechanoceptors (Ferrell et al 1988; Koltzenburg et al 1994; Raja et al 1988; Schmidt et al 1994) and the five-fold increase in resting discharge of an articular nerve from an inflamed joint (Schmidt 1990) would mean that spinal cord neurones receive an unusually large barrage of nociceptive inflammation from inflamed deep tissue. These are the conditions thought to be required for intracellular changes in WDR neurones that would make them hyperresponsive (Dickenson & Sullivan 1990; 1987; Thompson & Woolf 1991; Urban & Randic 1984). Investigations demonstrate that if a source of ongoing nociceptor input continuously "refreshes" the hyperexcitable state of the dorsal horn neurones (Gracely et al 1992) then this may lead to the loss of function of the auto-inhibitory inter-neurones between the WDR and NS neurones (Alkon &Rasmussen 1988; Collingride & Singer 1990; Laird & Bennett 1993; Nishizuka 1989). Clinically, hyperexcitability of WDR neurones may result in motor abnormalities such as the marked and prolonged increase in the flexion withdrawal reflex, as exhibited in rats (Ferrell et al 1988; Woolf 1983; Woolf et al 1994). The rat will try to avoid contact of the inflamed paw with the ground (Woolf 1984; Woolf & McMahon 1985; Woolf & Wall 1986). A similar situation may arise in humans whereby joint movements are prevented by increased muscle activity so as to minimise the mechanical input onto inflamed mechanoceptors. Lack of movement may be postulated to effect blood flow with a resultant exacerbation of oedema and/or ischaemia. Furthermore, lack of movement may be postulated to result in decreased non-noxious mechanical input that may be required for the modulation of electrical activity in both WDR and NS neurones. Therefore, lack of movement is likely to result in pain.
Further, more potent neurotoxic effects on autoinhibitory interneurones may occur due to ectopic input onto WDR neurones from a nerve subject to constriction (Dubner 1991; Sugimoto et al 1990). Animal models using ligatures around the sciatic nerves demonstrate large increases in spontaneous discharges in large and small diameter myelinated afferents, whilst leaving small diameter unmyelinated afferents unaffected (Bennett & Xie 1988). Thus, inflammation within the nerve itself and at peripheral nerve terminals in the limb and/or around the nerve itself may contribute to decreased modulation of pain at the spinal cord level. Conceivably, therapeutic intervention which decreases the mechanical irritation, normalises blood flow and also activates the sympathetic nervous system's (SNS) neuromodulation of inflammation, muscle activity and blood flow may also activate WDR modulation of NS neurones and hence decrease pain.
The effect of manual therapy on muscle activity around the intervertebral foramen (IVF).
Manual therapy may be directed at reducing muscle spasm. It is conceivable that sustained techniques may have a direct effect on the stretch reflex of muscles. Alternatively, a sustained technique (e.g. traction) may decrease electrical activity in type III and IV fibres through normalisation of blood flow and decreased mechanical pressure generated by inflammation on soft tissue structures in and around the IVF. Indeed, only 30mmHg pressure is required to obliterate endoneurial venous return (Lundborg 1988). Finally, non-noxious input from gentle oscillatory pressures may generate sufficient WDR modulation of NS neurones to allow decreased muscle spasm and increased functional muscle activity to take place. Any decrease in pain should be followed by functional exercises to maintain soft tissue integrity. Further, examination of the neurological signs and symptoms, and the painful active movements should be examined to demonstrate the effects of treatment.
The dosage of manual therapy and the significance of the 'stage' of inflammation and 'irritability' on '24 hour behavior', 'current' and 'past history'.
The stage of the inflammation and the 'irritability' (Maitland 1986; 1991) may influence the treatment approaches under consideration. For example, in an 'irritable' dysfunction and/or during the acute stage of injury the non-neurogenic inflammatory process may be more beneficially affected by sustained mobilisation techniques or constant traction which are thought to relieve the pressure around the nerve tissue. If this hypothesis were clinically true, then neurological changes such as reduced muscle power, reduced reflexes and reduced sensation should improve if the correct technique (position and amount of force) are used. During the later stages of inflammation and/or in a 'non-irritable' dysfunction the clinical signs and symptoms may be more readily influenced by treatments (e.g. joint mobilisations, mobilisations of the SNS, taping) specifically directed at the neurogenic inflammation. Treatment directed at the neurogenic inflammation must ascertain the status of the receptor thresholds with the aim of treatment being a decrease of afferent electrical activity through an increase in the modulation of the receptor thresholds of the type III and IV mechanoceptors. The principles of these hypotheses involve the fact that if inflammation results in a decrease in the receptor thresholds and a decrease in the modulation of electrical activity in type III and IV fibres, then the reverse should be true as inflammation resolves. That is, receptor thresholds and modulation of afferent electrical activity should increase. The expected result is decreased pain and consequent increases in ranges of movement, normalisation of voluntary muscle power, sensory discrimination and reflexes. Improvement in the clinical status of the patient should simultaneously correlate with improvements in the 'irritability' and '24 hour behaviour' of the dysfunction. In this manner the practitioner must treat the pain and not just any pain of which the patient complains (figure 7).
If oscillatory mobilisation techniques are employed at a 'stage' too early during the inflammatory process (i.e. in a worsening condition [e.g. distal pain > proximal pain] and/or in an 'irritable' dysfunction and/or progressing ischaemic compromise of a nerve root/DRG/spinal nerve), then this may exacerbate muscle spasm directly due to a stretch reflex or indirectly due to activation of inflamed receptors and neural compromise. Summation of afferent electrical activity from inflamed receptors may result in pain and further 'splinting' of the joint. Under no circumstance should an examination process or technique be used that increases neural compromise. Hence specificity of dosage is crucial not only for optimal results but also for safety.
Importantly, the clinician will need to ascertain the expectations of treatment outcome in relation to the 'stage' and 'irritability' which may be questioned in the subjective examination through not only the '24 hour behaviour' but also through ascertaining the 'current' and 'past history' of the signs and symptoms. In this manner improvements or deterioration in the patient's condition may be monitored and attributed to either the consequences of the type and dosage of treatment or to the consequences of the natural progression of the pathology.
Descending inhibition in the modulation of pain.
It is quite likely that the sympathetic nervous system (SNS) is involved in very specific but very different ways depending on the stage of inflammation and the 'irritability' of the dysfunction. The peripheral modulation of inflammation by the SNS (discussed previously) may be quite distinct and more readily influenced by enhanced blood flow, reduced oedema and reduced muscle spasm due to movement of inflammatory exudate. However, in presence of reduced autoinhibitory interneurone modulation of pain (in the spinal cord by WDR neurones on NS neurones) then at least two potential sources of descending neuromodulation may be recruited. One source of descending inhibition involves pontine noradrenergic projections onto ventral and dorsal horn neurones involved with the modulation of pain (figure 8) (see Proudfit 1992 for review; Jaenig 1985; Morgan et al 1989; Nakagawa et al 1990; Post et al 1986; Ren et al 1990). Descending noradrenergic inhibition is considered to be an opioid-independent form of analgesia (Proudfit 1992) however, evidence exists which supports the view that m -opioid and a -2 noradrenergic receptors are functionally linked to pain modulation (Kalso et al 1993). Apart from animal investigations for descending sympathetic pain modulation, further evidence comes from clinical investigations where the sensory and affective aspects of ischaemic pain (Maixner et al 1990) and muscle spasm (Shindo et al 1994) correlate with SNS induced cardiovascular responses.
Figure 8 : Descending modulation of pain (adapted from Wall 1995)
Manual therapy and descending modulation of pain.
Investigations of grade III PA oscillatory mobilisation (Maitland 1986) of the cervical spine (C5/6) demonstrated an initial sympathoexcitatory effect which started very rapidly (within 15 seconds) after the commencement of treatment (Petersen et al 1993). Wright & Vicenzino (1995) attributed the modulation of the sympathoexcitatory effect on the dorsal periaqueductal grey (dPAG) via nucleus paragigantocellularis, using noradrenaline as the transmitter substance. A review (by the investigators) of the acupuncture literature suggested that this initial sympathoexcitatory effect might be followed by sympathoinhibition some 20-45 minutes later (Wright & Vicenzino 1995). This sympathoinhibition was postulated to be as a result of modulation by the ventral PAG (vPAG) via the nucleus raphe magnus (NRM) to the dorsal horn and intermediolateral horn (IML) of the spinal cord to effect analgesia and cardiovascular changes. The connection from the nucleus raphe pallidus and obscurus to the IML and anterior horn is thought to influence motor activity and autonomic function (Lovick 1991, cited by Wright & Vicenzino 1995). These preliminary results are interesting, as there are very few adequate studies that have investigated the neurophysiology of the analgesic effects of manual physiotherapy.
Sensorimotor "centre-surround inhibition" of pain.
Apart from the SNS, another source of descending modulation of pain is considered to arise from the sensorimotor cortical regions involved with input on spinal cord and brainstem regions (Hsieh, Stahle-Backdahl, Hagermark, Stone-Elander, Rosenquist, Ingvar 1995; Wall 1995). Wall (1995) describes this system as setting a "sensory posture" whereby motor input exerts 'powerful' control over afferent spinal cord processing which 'focuses on action rather than perception' (p35) (also Galea & Darian-Smith 1995). Wall (1995) used positron emission tomography (PET) studies in patients with chronic pain to substantiate this claim whereas Galea & Darian-Smith (1995) used PET and anatomical dissection of primates. Further evidence for descending modulation comes from Gogas et al (1991) where supraspinal opioids were found to block the perception of pain through a 64% reduction in superficial laminae dorsal horn activity (usually associated with a predominance of nociceptive specific [NS] neurones (Lima et al 1994)) and an 85% reduction in ventral horn activity (usually associated with motor activity) (Schomburg & Steffens 1991). Investigations substantiated the finding that higher centres can act in an antinociceptive manner where a predominance of inhibition occurs at NS neurones but where excitation or inhibition occurs with equal frequency on wide dynamic range (WDR) neurones (Sandkuehler et al 1995). This appears to be a unique way of looking at pain perception where the cortical input is primary to a secondary ascending nociceptive stimulus. This arrangement is postulated to improve discrimination of NS neuronal activity and thereby possibly decrease pain (figure 9) (Bogduk 1993; Laird & Cervero 1990).
Figure 9 : Centre – Surround Inhibition (Bogduk 1993)
The focus on action with functional tape and motor control in the treatment of pain.
The clinical application of functional tape and specific motor control suggest a marked pain inhibitory effect beyond that which may be explained purely on biomechnical grounds. Since primary hyperalgesia in deep tissue may lead to secondary hyperalgesia in superficial structures then therapeutic intervention, which results in a decrease in secondary hyperalgesia, may be postulated to result in increased movement.
Evidence for descending inhibition comes from a recent study on the modulation of cutaneous nociception concluded that besides the brainstem, other higher regions may be responsible for the marked descending inhibition of nociception (Hsieh et al 1995; Morton, Siegel, Xiao, Zimmermann 1997). Specifically, the somatosensory-motor cortex has been postulated to be involved in movement dysfunction as a consequence to and as a consequence of pain. It is conceivable that the cutaneous feedback from tape and the decrease in noxious afferent input may increase the discriminatory role of descending inhibition. Further, the specificity of motor control may also increase the descending inhibition of nociception.
Evidence for the effect of pain on the specificity of motor control comes from investigations into low back pain. Altered patterns of abdominal muscle activation with arm or leg movements have been recorded in patients with chronic low back pain (O'Sullivan, Twomey, Allison, Sinclair, Miller, Knox 1997; Hodges and Richardson 1996; Hodges, Richardson, Jull 1996; Richardson and Jull 1995). Therefore, the role of specific exercise, specific functional tape, and specific feedback may be to modulate pain and improve muscular co-ordination.
Apart from tape and specific exercise, feedback may come in the form of demonstrating improvements in the signs and symptoms both to you and the patient. Demonstrating improvements in the symptoms may be possible only through a very discriminative subjective examination (figure 7). A discriminative subjective examination may use the Maitland (1986, 1991) approach as well as pain questionnaires such as McGill, Oswestry, etc. Further, the improvements in the clinical signs may occur through range of movement testing, pressure biofeedback, EMG biofeedback and the testing of neurological signs and neurological tension tests. Finally the ability of the manual therapist to discriminate the site of pathology in the spine has been demonstrated to be valid and reliable and to have high inter-examiner reliability (Jull, Zito, Trott, Potter, Shirley, Richardson 1997). This means that both the therapist and the patient are able to judge the effect of treatment technique and dosage on the current 'stage' of the dysfunction if an organised assessment and treatment procedure is implemented.
Group III/IV muscle afferent feedback on endurance exercise performance
Feedback from group III/IV muscle afferents increases with the onset of locomotion and influences key determinants of exercise performance, including the development of peripheral and central fatigue. In this capacity, they influence the circulatory and ventilatory response to muscle oxygen delivery, through a feedback mechanism. They can also restrict motoneuronal output and locomotor muscle activation, thereby by limiting endurance performance, through facilitation of central fatigue. This latter impact, is a result of 'upstream' (of motor cortex) inhibition of 'descending voluntary drive' by group III/IV mediated depression of motor cortical excitability (Amann et al 2020, Ex Sp Sc Rev, 48, 4, 209-2016).
Game theory and variability of the 'outlier' for adaptability
It is interesting to speculate that both the novice and elite orienteer are more susceptible to infection because they both have more rigid motor patterns, are less inclined to take risk and therefore are less likely to be confronted with error generating patterns of correctability? The assumption underlying game theory is that there is a resource over which there is a conflict.
A factor which the orienteering paradigm partially defines, and identifies, is the freedom of thought and movement. That fact that many investigations are looking at exercise and the immune system, using captive animals, might be problematic in itself. These animals are in a predictable environment, which for this purpose is ethical, reductionist and conforms with rigorous scientific research protocols, which is practical, as it reduces the number of 'dependent' and 'independent' variables. However, from an evolutionary point of view, and from the perspective of the example used here, where in orienteering, more may be learnt and fine-tuned, in an unpredictable variable environment, whereby the use of caged animals may be limiting the validity of the paradigm (deterministic chaos) which is under investigation. Moreover, in terms of cognition, confinement is a stressor. Moreover, the calmness and clarity of thought needed in the freedom of orienteering (running and navigating) through the landscape can be considered the antithesis of the caged animal.
Our ancestors were striving for energy security through appeasement, subjugation or dominance over other life forms, both internally and externally. In this sense, the 'freedom to navigate and move' paradigm, suggests that our evolutionary forefathers, used their muscles, to propel themselves out of Africa, for 'greener gut biome pastures'. Therefore, maintaining good health in new and potentially 'dangerous environments', involved an unpredictable deterministic variable. As it pertains to cognition, it is an intriguing idea that a motor-sensory curiosity, drove a mechanism, which simultaneously caused muscle hypertrophy, and endowed the muscles with enhanced glutamine and cytokine concentrations, which were needed, if an immune response to pathogens was encountered. Additionally, it is conceivable, that the gut biome was driven by the laws of thermodynamics, in the search for energy. Subsequently, the gut-environment interface provided the interaction needed, to both provide energy for movement, allowed the immune system the encounters needed to flourish, and achieved the abundance of gut species required, in a variety of situations, from feast to famine. Therefore, the gut - muscle - brain cognitive pathway, was driven at a conscious and subconscious level to meet the demands of thermogenesis and immune competency, resulting in collective gain amongst all cells which required energy. Akin to Zen Buddhist philosophy, suggestions are, that the constant sensation of mild hunger, drives the clarity of thought needed, to strive for all encompassing meaning and ultimate enlightenment. Yoga, using animal poses, to stretch muscles and enhance breathing, whilst calming the cognitive state, may be based on the same primeval paradigm, of what is good for muscles is also good for the gut and brain.
The 'dove and hawk' paradigm in game theory is interesting. If a hawk and dove compete over the same resource, direct open conflict of the dove with the hawk would be suicidal. Hence, one would think it's better to be a hawk. However, what if two hawks meet, there will be only one winner and potentially both could be injured for the same net gain. Whereas, if two doves meet, they may postulate and gesticulate and eventually one may retreat or they may even share the resource, with the less risk of injury. Hence, the stakes for the Hawk are much higher. Humans have always been in conflict for resources. Does this mean that the immune system is tuned by adaptation to 'individual' resource dominance? Or, as people developed and evolved as tribes, into communities did our immune systems come to share pathogens, which may have entailed 'herd immunity' but at the same time, gave humans a lack of species variability, making them more vulnerable to 'novel' pathogens? Even more intriguing, is the notion that within a group of similar, the weakest may be driven out, seeking new resources, which in this case means new environments and new pathogens, invoking an 'immune enriching' response?
Continuing with the 'hawk dove' analogy, if we have too many hawks in a population, the consequences are constant conflict. If too many doves, constant compromise. In fact, a single dove in a hawk environment might be totally ignored, as might a single hawk in a dove environment. Thus, the apparent weaker species could be at an advantage when it's the outlier? To carry this further, we could postulate that the hawk is more prone to injury. Does this mean that in humans, the more dominant 'aggressive' individuals have an immune system which is more in demand for potential or actual injury? Whereas, the postulating dove, activates it's immune system minimally when it's performing some form of escape or deception? Interestingly, most animal conflict encounters, go out of their way to avoid injuries to themselves. Regardless, it's likely, that in both 'stressful' situations, the immune and musculoskeletal systems are activated, in a proportionately preparatory manner. Thus, the stronger the variability in the individual, the more proportional, and therefore robust their immune response.
Needless-to-say, a balance between hawks and doves needs to be established for mutual gain to take effect. In terms of the human genome, it's very underwhelming, yet it has evolved to a complex multi-cellular life form, still totally dependent upon trillions of unicellular life forms within the individual gut biome. This flies in the face of Darwinian evolution and the survival of the fittest, in that simple life forms keep complex life forms alive. Even, within the gut biome, there appears to be a symbiotic relationship with parasites and a healthy immune system (i.e. parasitic exposure appears to reduce auto-immune disease such as allergies). A 'simple' multitude (gut biome) balanced with a 'complex' minority (human DNA). Humans eat to feed their gut, their gut breaks down energy from food, which in turns propels the human, with the energy gained, to find more food. A net win win situation using the gut-brain-muscle axis.
In terms of muscles, a simplistic view, (using this analogy) would be that the glycolytic (fast twitch) muscles are the 'hawks', whereas the oxidative (slow twitch) muscles are the 'doves'. The glycolytic muscle fibres tend to be ballistic two joint (mechanical) energy straps which propel the body, whereas the oxidative endurance (metabolic energy) muscles are one joint deep muscles tending to stabilise joints and prevent injury. Therefore, the 'hawks' make the large perturbations whereas the 'doves' dampen them. Luckily, there is a muscle glycolytic fibre type which can become more oxidative (endurance power). Hence, 'hawks' which can be tempered towards a 'dove' like mentality....a balance between metabolic and mechanical energy systems, where the mechanical perturbations stimulate the metabolic-immune response.
In terms of neurophysiology, this analogy could potentially be taken further, where the sympathetic nervous system is the 'hawk' and the para sympathetic nervous system are the 'doves'. Fortunately, within the sympathetic nervous system there are self modulating ('dove' like) perturbating mechanisms. But it could be envisaged that putting a 'hawk' amongst the 'doves' wakes them up from a state of complacency. Similarly, 'staleness' is an 'existential threat' to any training regime and to any 'immune system'.
Activation of Vastus Medialis and Vastus Lateralis in females with Patellofemoral Pain
Imbalances between the quadricep muscles on the inside and outside of the knee cap have been used clinically for many decades to explain knee pain at the front of the knee, a.k.a anterior knee pain or patellofemoral pain (PFP). Investigators using high density surface EMG of the Vastus Medialis (VM) and Vastus Lateralis (VL) have shown 2 different types of PFP in a group of 36 females. One clinical presentation is that of weaker knee extensor (quadriceps) strength but more subtle fine tuning between the two muscles with a tendency of VMO to work preferentiially during eccentric (muscle lengthening) contractions, whilst VL worked preferentially during concentric (muscle shortening) contraction. Whereas the other presentation was the inverse where stronger knee extensor (quadriceps) strength was accompanied by less differentiated VM : VL task specific function (Gallina et al 2018 Med Sc Sp Ex, 51, 3, 411-420).
Cortical 'resource' representation, mapping, in knee muscles, after injury
In the context of physiotherapy, a simple model of game theory might be applied to the problem of anterior knee pain. Commonly, this problem is associated with pain at the front of the knee when it is in flexion (a bent position), such as stair climbing, cycling, squats, etc. The conventional wisdom is that the patella (knee cap) is mal-aligned due to a lack of medial (VMO) muscle activity pulling the patella inwards and too much activity of the lateral thigh muscle (VL) pulling it outwards. Game theory could be applied here as the muscles compete for finite cognitive territory to represent their individual (rather than mutual) function, where ultimately neither muscle gains, both loose out to pain generating cortical representations, reducing fidelity and increasing noise in the system. However, if the muscles were to readjust for a functional outcome, they would do so through gaining a synergy of proportionally shared resources (power sharing), hereby a dominance over pain and dysfunction is gained. Physiotherapists, use functional electrical muscle stimulation (FEMS) to give added 'resources' to the VMO, which then can be used during functional exercise training. As the system adjusts, the pain improves and the gain experienced by all the muscles convinces the VL to fire with the VMO, hamstrings and gluteals in a functional synergy for stairs, cycling (see previous), squats, etc. Hereby, game theory would suggest all have won and injury has been avoided.
Investigations in Australia, by the Brazilian, Abrahao Baptista (2014), looking at 40-50 year old women with chronic knee pain, demonstrated the significant reduction in the volume of muscle representation in the cerebral cortices, as well as changes in the location of these muscle representations (see below). Moreover, in the context of neurons who 'fire together, wire together' it would be of utmost importance to find exercises that act as functional synergies and relate in a real or a 'virtual' manner to the environmental context in which they need to fire. This also becomes particularly important in psychological behavioural issues of 'fear avoidance' and disuse atrophy. Ideally rehabilitation stimulates 'wiring and firing together' of goal-oriented regions of the brain rather than those which are directed at fearing and avoiding movement. Therapist must instil confidence through their choices of treatment whereby they outline and hence monitor the expectations of outcome.
In this picture, it is clear that, the volume of the quadriceps muscle representation in the cortex of people with anterior knee pain (PFP = patello femoral pain) is dramatically reduced. Not seen here, but demonstrated in other research, is the phenomenon of pain processing altering cortical activity in various brain areas (see below).
Individuals with patellofemoral pain (PFP) had reduced map volumes and an anterior shift in the M1 representations, greater overlap of the M1 representation and a reduction in cortical peaks across all three quadriceps (RF, VL, VMO) muscles compared with controls.(Te et al 2017 Pain Medicine, pnx036, https://doi.org/10.1093/pm/pnx036). Physiotherapists use FEMS (30HZ functional electromuscular stimulation) to enhance muscle cortical representation in the brain, which improves function and in turn improves pain. FEMS stimulation readjusted cortical mapping to that seen in asymptomatic individuals. Alternatively, therapists use trans-cortical stimulation of the pre-frontal cortex to improve 'executive function' and pain.
Brain activation related to spatial discrimination of noxious stimuli is distinct from that related to perceived pain. These images are located at x = 0 mm, x = 30 mm, z = 5 mm, and y = –30 mm in standard stereotaxic space. IPL/SPL, Inferior parietal lobule/superior parietal lobule; GP/PT, globus pallidus/putamen; M1, primary motor cortex; DISCRIM., discrimination. (Oshiro et al 2007 J Neuroscience, 27, 13, 3388-3394)
Abrahao Baptista (2020) and his colleagues are conducting research into trans-cortical stimulation and vagal (para-sympathetic) nerve stimulation in the treatment of patients with COVID-19. They are basing their assumptions and working hypothesis on some positive results a rheumatologist has had with this methodology for the treatment of auto-immune inflammatory disease. COVID-19 has many of the hallmarks of an auto-immune disease, including the cytokine storm. A treatise, elsewhere on this site, has argued that sympathetic, rather than para-sympathetic, stimulation is necessary to add a deterministic chaotic input which perturbs the immune system into action. It would be intriguing to speculate a large perturbation between sympathetic and para-sympathetic can also activate the immune response. In this case, the illness has already set the sympathetic nervous into a heightened chaotic state, which needs additional buffering (redundancy) from the vagal nerve stimulation.
Conclusions: The need for a thorough subjective and physical examination to be able to make clinical decisions, to apply the correct technique and dosage, and to assess the expected treatment outcome.
The clinical implications of descending modulation of pain suggest that during the application of manual physiotherapy to the cervical spine a noticeable treatment effect may occur within 15 seconds of mobilisation. Furthermore, it would appear that if mobilisation does result in a focus by the patient on 'action', then it is imperative to re-examine the active movement (incl. combined active movement) which initially reproduced the patient's pain.
Since descending modulation involves a principle of "fine tuning" of the perception of pain, then the initial examination must be very discriminative as to the exact area and range of movement where pain occurs during active movements. Also the 'quality' and 'intensity' of pain and the 'relationship' between the pains must be noted since secondary mechanical hyperalgesia and spinal cord hypersensitisation may occur as a result of neurogenic inflammation.
Movement aberrations/inco-ordinations due to muscle spasm and/or due to muscle weakness, decreased reflexes and sensation should be noted and correlated with known anatomical innervations.
Meticulous recording of information may allow the practitioner to use their cognitive processing for analysis rather than for remembering. By implication, the questioning of the patient through the clinical reasoning process may be hypothesised to also aid the patients' cognitive processing and hence modulation of pain.
The information from the examination of active movements should correlate with the 'aggravating/easing factors' and '24 hour behaviour' of the pain as well as with 'stage', 'stability' and 'irritability' of the dysfunction. Only with a discriminative subjective examination will it be possible for the practitioner to focus their clinical reasoning skills in search of the pain (not any pain) during their physical examination. However the practitioner may never know the effect of treatment if the initial examination has left the practitioner with nothing on which the practitioner nor the patient can judge the expectations of treatment outcome (see Mechanical traction - clinical example of neurophysiological and biomechanical pain modulation?) . Finally, visualisation, verbalisation and goal orientation have powerful influences on motor learning. Improved motor performance reduces the likelihood of re-injury through increased awareness of the correct patterning of movements (see Motor Learning and Orienteering expertise ) . This, in turn will improve the force closure required for stability around a joint (see Pelvic Girdle Pain - muscle energy techniques - Swiss Ball).
Many dysfunctions will improve with time, however the discriminatory practitioner should be able to predict treatment outcome and either minimises the period of pain and/or prevent an acute injury from becoming chronic by applying the optimal dosage of treatment.
Conceptualised and written by Martin Krause for lectures presented between 1997 and 1999. Since this time an overwhelming body of evidence supports the neurogenic modulation of pain and inflammation in cortical, subcortical, cerebral, spinal cord, dorsal root ganglion, peripheral sympathetic nervous system and afferent somatic nervous system sites. Undoubtedly, the cortical involvement highlights the importance of explanations and education of your patient during treatment. Feedback, both visual and verbal, as well as realistic goal setting appear to be of paramount importance for involving the patient in their recuperation (Martin Krause 2004 and 2020).
- Motor Learning and gaining of expertise through avoidance of injury
- Chronic Low Back Pain
- Immune Responses
- Fibromyalgia
- Stability
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Initially written June 1995, Last update : 1 December 2020